Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/221140
Title: PVR–CD226 interaction regulates IL-10 production during human T cell differentiation
Author: Lozano Garcia, Ester
Mena, Mari-Pau
Díaz Sánchez, Tania
Rosiñol Dachs, Laura
Keywords: Cèl·lules T
Mieloma múltiple
T cells
Multiple myeloma
Issue Date: Apr-2025
Publisher: BMJ Publishing Group
Abstract: Presence of plate-bound PVR or nectin-2 at 2 µg/mL did not significantly modify cell viability nor frequency of proliferating cells compared to isotype control. As expected, Treg conditions significantly increased FoxP3 expression (paired T test p<0.0001, n=6) which was accompanied by elevation of CD226 levels (p=0.0026). Surprisingly, Treg conditions led to reduction of TIGIT expression (p=0.0039) and CD96 (p=0.084). In addition, PVR ligation resulted in a higher frequency of IL10-producing cells in Th0 conditions (p=0.0193), most of them expressing high levels of CD226 (78.48% ± 2.324), CD96 (59.87% ± 4.032), and to a lesser extent, TIGIT (39.82% ± 4.043). Consistently, under these experimental conditions dual blockade of TIGIT and CD96 did not abrogate the increase in the percentage of IL-10 producing cells, suggesting that PVR binds CD226 expressing cells to upregulate IL-10 production.
Note: Reproducció del document publicat a: https://doi.org/10.1136/jitc-2025-ITOC11.16
It is part of: Journal for ImmunoTherapy of Cancer, 2025, vol. 13, num.Supplement 1, p. A10-A10
URI: https://hdl.handle.net/2445/221140
Related resource: https://doi.org/10.1136/jitc-2025-ITOC11.16
ISSN: 2051-1426
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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