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Title: | PVR–CD226 interaction regulates IL-10 production during human T cell differentiation |
Author: | Lozano Garcia, Ester Mena, Mari-Pau Díaz Sánchez, Tania Rosiñol Dachs, Laura |
Keywords: | Cèl·lules T Mieloma múltiple T cells Multiple myeloma |
Issue Date: | Apr-2025 |
Publisher: | BMJ Publishing Group |
Abstract: | Presence of plate-bound PVR or nectin-2 at 2 µg/mL did not significantly modify cell viability nor frequency of proliferating cells compared to isotype control. As expected, Treg conditions significantly increased FoxP3 expression (paired T test p<0.0001, n=6) which was accompanied by elevation of CD226 levels (p=0.0026). Surprisingly, Treg conditions led to reduction of TIGIT expression (p=0.0039) and CD96 (p=0.084). In addition, PVR ligation resulted in a higher frequency of IL10-producing cells in Th0 conditions (p=0.0193), most of them expressing high levels of CD226 (78.48% ± 2.324), CD96 (59.87% ± 4.032), and to a lesser extent, TIGIT (39.82% ± 4.043). Consistently, under these experimental conditions dual blockade of TIGIT and CD96 did not abrogate the increase in the percentage of IL-10 producing cells, suggesting that PVR binds CD226 expressing cells to upregulate IL-10 production. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/jitc-2025-ITOC11.16 |
It is part of: | Journal for ImmunoTherapy of Cancer, 2025, vol. 13, num.Supplement 1, p. A10-A10 |
URI: | https://hdl.handle.net/2445/221140 |
Related resource: | https://doi.org/10.1136/jitc-2025-ITOC11.16 |
ISSN: | 2051-1426 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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