Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/221188
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DC Field | Value | Language |
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dc.contributor.author | López-Corrales, Marta | - |
dc.contributor.author | Izquierdo-García, Eduardo | - |
dc.contributor.author | Bosch Marimon, Manel | - |
dc.contributor.author | Das, Tapas | - |
dc.contributor.author | Llebaria Soldevila, Amadeu | - |
dc.contributor.author | Josa-Culleré, Laia | - |
dc.contributor.author | Marchán Sancho, Vicente | - |
dc.date.accessioned | 2025-05-23T13:37:34Z | - |
dc.date.issued | 2025-04-28 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | https://hdl.handle.net/2445/221188 | - |
dc.description.abstract | Photocleavable protecting groups hold great promise in photopharmacology to control the release of bioactive molecules from their caged precursors within specific subcellular compartments. Herein, we describe a series of photocages based on a COUPY scaffold, incorporating chlorambucil (CLB) and 4-phenylbutyric acid (4-PBA) as bioactive payloads that can be efficiently activated with visible light. Confocal microscopy confirmed the preferential accumulation of CLB and 4-PBA N-hexyl COUPY photocages in the mitochondria, which exhibited aremarkable phototoxicity against cancer cells upon green-yellow light irradiation, with IC50 values in the nanomolar range. This effect was attributed to a synergistic mechanism involving the photorelease of the bioactive payloads and the intrinsic photogeneration of Type I and Type II ROS by the COUPY scaffold within mitochondria. Thus, COUPY-caged derivatives of CLB and 4-PBA underscore the potential of COUPY-caging groups as a versatile platform to develop innovative light-activated agents operating simultaneously through photodynamic therapy and photoactivated chemotherapy. | - |
dc.format.extent | 1 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.jmedchem.5c00550 | - |
dc.relation.ispartof | Journal of Medicinal Chemistry, 2025 | - |
dc.relation.uri | https://doi.org/10.1021/acs.jmedchem.5c00550 | - |
dc.rights | (c) American Chemical Society, 2025 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Mitocondris | - |
dc.subject.classification | Cumarines | - |
dc.subject.classification | Fototeràpia | - |
dc.subject.other | Mitochondria | - |
dc.subject.other | Coumarins | - |
dc.subject.other | Phototherapy | - |
dc.title | Exploring the Phototherapeutic Applications of Mitochondria-Targeted COUPY Photocages of Antitumor Drugs | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 758512 | - |
dc.date.updated | 2025-05-23T13:37:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | - |
dc.embargo.lift | 2026-04-27 | - |
dc.date.embargoEndDate | info:eu-repo/date/embargoEnd/2026-04-27 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
Files in This Item:
File | Description | Size | Format | |
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893829.pdf | 962.16 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el
27-4-2026
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