Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/221188
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dc.contributor.authorLópez-Corrales, Marta-
dc.contributor.authorIzquierdo-García, Eduardo-
dc.contributor.authorBosch Marimon, Manel-
dc.contributor.authorDas, Tapas-
dc.contributor.authorLlebaria Soldevila, Amadeu-
dc.contributor.authorJosa-Culleré, Laia-
dc.contributor.authorMarchán Sancho, Vicente-
dc.date.accessioned2025-05-23T13:37:34Z-
dc.date.issued2025-04-28-
dc.identifier.issn0022-2623-
dc.identifier.urihttps://hdl.handle.net/2445/221188-
dc.description.abstractPhotocleavable protecting groups hold great promise in photopharmacology to control the release of bioactive molecules from their caged precursors within specific subcellular compartments. Herein, we describe a series of photocages based on a COUPY scaffold, incorporating chlorambucil (CLB) and 4-phenylbutyric acid (4-PBA) as bioactive payloads that can be efficiently activated with visible light. Confocal microscopy confirmed the preferential accumulation of CLB and 4-PBA N-hexyl COUPY photocages in the mitochondria, which exhibited aremarkable phototoxicity against cancer cells upon green-yellow light irradiation, with IC50 values in the nanomolar range. This effect was attributed to a synergistic mechanism involving the photorelease of the bioactive payloads and the intrinsic photogeneration of Type I and Type II ROS by the COUPY scaffold within mitochondria. Thus, COUPY-caged derivatives of CLB and 4-PBA underscore the potential of COUPY-caging groups as a versatile platform to develop innovative light-activated agents operating simultaneously through photodynamic therapy and photoactivated chemotherapy.-
dc.format.extent1 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/acs.jmedchem.5c00550-
dc.relation.ispartofJournal of Medicinal Chemistry, 2025-
dc.relation.urihttps://doi.org/10.1021/acs.jmedchem.5c00550-
dc.rights(c) American Chemical Society, 2025-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationMitocondris-
dc.subject.classificationCumarines-
dc.subject.classificationFototeràpia-
dc.subject.otherMitochondria-
dc.subject.otherCoumarins-
dc.subject.otherPhototherapy-
dc.titleExploring the Phototherapeutic Applications of Mitochondria-Targeted COUPY Photocages of Antitumor Drugs-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec758512-
dc.date.updated2025-05-23T13:37:35Z-
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess-
dc.embargo.lift2026-04-27-
dc.date.embargoEndDateinfo:eu-repo/date/embargoEnd/2026-04-27-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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