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https://hdl.handle.net/2445/221269| Title: | Light-Activated Pharmacological Tools for Exploring the Cholinergic System |
| Author: | Colleoni, Alessio Galli, Giulia Dallanoce, Clelia Amici, Marco de Gorostiza Langa, Pablo Ignacio Matera, Carlo |
| Keywords: | Fotofarmacologia Bioquímica Receptors colinèrgics Photopharmacology Biochemistry Acetylcholine receptors |
| Issue Date: | 23-Mar-2025 |
| Publisher: | Wiley |
| Abstract: | Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1002/med.22108 |
| It is part of: | Medicinal Research Reviews, 2025 |
| URI: | https://hdl.handle.net/2445/221269 |
| Related resource: | https://doi.org/10.1002/med.22108 |
| ISSN: | 1098-1128 |
| Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2025_MedResRev_Light_GorsotizaP.pdf | 1.34 MB | Adobe PDF | View/Open |
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