Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/221506
Title: | Childhood Maltreatment and Cognitive Functioning in Bipolar Disorder: A Systematic Review and Meta-Analysis |
Author: | Fares Otero, Natalia Elena Pérez Ramos, Anaid López Escribano, Ricardo Martín Parra, Sara Alameda, Luis Halligan, Sarah L. Miskowiak, Kamilla W. Vieta i Pascual, Eduard, 1963- |
Keywords: | Trastorn bipolar Infants maltractats Metaanàlisi Manic-depressive illness Abused children Meta-analysis |
Issue Date: | 6-May-2025 |
Publisher: | John Wiley & Sons |
Abstract: | Aims Characterising the association between childhood maltreatment (CM) and cognitive functioning in bipolar disorder (BD) is crucial for improving the understanding of how early environmental risk factors impact the presentation of the disorder. We conducted a systematic review and meta-analysis to estimate associations between overall and subtypes of CM, global cognition/IQ, and five cognitive domains in BD (attention/processing speed, verbal memory/learning, working memory, executive functions/verbal fluency, and social cognition), and to explore moderators/mediators in these associations. Methods A systematic search was performed on 24 June 2024 to identify published peer-reviewed articles in six databases (PROSPERO-CRD42023468641). Results From 780 identified records, 20 studies were included, comprising 2457 individuals with BD (M ± SD, age in years = 39.5 ± 9.7; 41.3% males; BD type I = 81.2%); 152 effect sizes were pooled in random-effect meta-analyses. Overall CM was negatively associated with global cognition/IQ, attention/processing speed, and verbal memory/learning (r = −0.14 to −0.18, p = 0.002 to < 0.001). Sexual/physical abuse and physical neglect were negatively associated with global cognition/IQ, working memory, and executive functions/verbal fluency (r = −0.07 to −0.18, p = 0.037 to < 0.001). Emotional abuse was negatively associated with working memory (r = −0.12, p = 0.002). Emotional neglect was unrelated to cognitive functions. CM (overall/subtypes) was unrelated to social cognition. Meta-regressions did not identify any consistent moderators. Narrative synthesis identified possible moderators/mediators. Associations were of small magnitude, and a limited number of studies assessing CM subtypes and cognitive functions are available. Conclusion CM exposure is associated with worse cognitive performance in people with BD, an effect observed across multiple maltreatment types and cognitive domains. Besides trauma-informed interventions, those with BD and CM require cognitive assessment and therapies to rehabilitate cognitive functioning. |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/acps.13813 |
It is part of: | Acta Psychiatrica Scandinavica, 2025 |
URI: | https://hdl.handle.net/2445/221506 |
Related resource: | https://doi.org/10.1111/acps.13813 |
ISSN: | 1600-0447 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) |
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