Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/221673
Title: Economic burden of secondary progressive multiple sclerosis: DISCOVER study
Author: Oreja-Guevara, Celia
Meca Lallana, José E.
Gomez-estevez, Irene
Ara Callizo, José Ramón
Hernández Pérez, Miguel Ángel
Gracia Gil, Julia
Alonso Torres, Ana María
Pilo De La Fuente, Belén
Ramio Torrentà, Lluís
Eichau Madueño, Sara
Gascón Gimenez, Francisco
Casanova, Bonaventura
Martínez Yélamos, Sergio
Aguado Valcarcel, Marta
Martínez Ginés, María Luisa
El Berdei Montero, Yasmina
López Real, Ana María
González Quintanilla, Vicente
López de Silanes, Carlos
Martínez Rodríguez, José Enrique
Costa Frossard, Lucienne
Garcés Redondo, Moises
Labiano Fontcuberta, Andrés
Castellanos Pinedo, Fernando
García Merino, Juan Antonio
Muñoz Fernández, Carmen
Castillo Triviño, Tamara
Meca Lallana, Virginia
Peña Martínez, Joaquín
Rodríguez Antiguedad, Alfredo
Prieto González, José María
Agueera Morales, Eduardo
Pérez Molina, Inmaculada
Solar Sánchez, Dulce M.
Herrera Varo, Nicolás
Aguirre Vázquez, Marta
Rodríguez Barrios, José Manuel
Río, Jordi
Keywords: Esclerosi múltiple
Cost de l'assistència sanitària
Cost
Multiple sclerosis
Cost of medical care
Cost
Issue Date: 10-Apr-2025
Publisher: Springer Science and Business Media LLC
Abstract: BackgroundTo estimate the socioeconomic burden of people with secondary progressive multiple sclerosis (pwSPMS), considering direct health care, direct non-health care, and indirect costs, and to evaluate the relationship between costs and patients' functional outcomes.MethodsObservational, cross-sectional, multicenter study with retrospective real-life clinical practice data collection from pwSPMS visiting the neurology services of 34 hospitals during 2019-2020. Clinical data included Expanded Disability Status Scale scores, number of relapses, magnetic resonance imaging, disease-modifying treatment (DMT), symptoms, and comorbidities from 24 months before the study visit. Resource use and allied costs were collected 12 months before the study visit. Patient-reported outcomes, functional and cognitive scales were also collected.Results70% of pwSPMS used primary care services, and nearly 50% needed assistance in a daycare or rehabilitation center. Almost 60% of the participants were receiving DMT at the study visit, and 80% needed support for domestic/housekeeping tasks. More than 90% were inactive at work, with nearly 80% taking early retirement. The estimated total annual cost per pwSPMS in Spain was almost 41,500, of which more than 50% (21,400) were indirect costs, followed by direct health care costs (30%, 11,300), and, finally, direct non-health care costs (about 20%, 8,800). Older patients with severe disabilities and worse functional outcomes incurred higher costs.ConclusionsSPMS is a major burden on health care systems, patients, and society as a whole. Health care and societal policies should be aimed at improving the SPMS care pathway and minimizing patients' funding of direct non-health care costs.Trial registrationThe trial is a non-interventional study. The NCC code is CBAF312AES01/NOV-EMS-2019-01.
Note: Reproducció del document publicat a: https://doi.org/10.1186/s12913-025-12592-1
It is part of: BMC Health Services Research, 2025, vol. 25
URI: https://hdl.handle.net/2445/221673
Related resource: https://doi.org/10.1186/s12913-025-12592-1
ISSN: 1472-6963
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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