Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/221726
Title: Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
Author: Ciccone, Giuseppe
Salmeron-Sanchez, Manuel
Keywords: Matriu extracel·lular
Materials biomèdics
Extracellular matrix
Biomedical materials
Issue Date: 13-Jun-2025
Publisher: Elsevier
Citation: Ciccone, Giuseppe; Salmeron-Sanchez, Manuel (2025). Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels. Curr Opin Biomed Eng, (), 100604-. DOI: 10.1016/j.cobme.2025.100604
Abstract: Over the past 30 years, polyacrylamide (PAAm) hydrogels have become essential tools to mimic the mechanical properties, chemical composition, and dimensionality of the extracellular matrix (ECM) in in vitro mechanobiology studies. This brief review highlights recent developments that have transformed PAAm hydrogels from simple 2D static elastic hydrogels to complex ECM-mimicking systems involving protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and the microfabrication of 3D systems. We focus on novel mechanobiological questions that have been elucidated using these platforms and give a perspective on the future of PAAm hydrogels for mechanobiology research.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.cobme.2025.100604
It is part of: Curr Opin Biomed Eng, 2025, vol. 35
URI: https://hdl.handle.net/2445/221726
Related resource: https://doi.org/10.1016/j.cobme.2025.100604
ISSN: 2468-4511
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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