Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222024
Title: Autocrine Wingless constricts the Drosophila embryonic gut by Ca+2-mediated repolarisation of mesoderm cells
Author: RICOLO, Delia
Tamba, Francesca
Casanova Roca, Jordi
Keywords: Astronomia / física
Biochemistry
Biochemistry & molecular biology
Biotecnología
Cell biology
Ciências biológicas i
Ciências biológicas ii
Ciências biológicas iii
Engenharias ii
General medicine
Genetics
Medicina i
Molecular biology
Saúde coletiva
Armadillo
Cell polarity
Constriction
Eb
Endoderm
Expression
Gene
Homolog
Mesoderm
Midgut
Proteins
Spastin
Wingles
Wingless
Issue Date: 7-Mar-2025
Abstract: Wg/Wnt signalling-a highly conserved transduction pathway-has most commonly been found to be involved in patterning, cell fate, or cell proliferation, but less so in shaping organs or body parts. A remarkable case of the latter is the role of Wg signalling in the midgut of the Drosophila embryo. The Drosophila embryonic midgut is divided into four chambers that arise by the formation of three constrictions at distinct sites along the midgut. In particular, Wg is responsible for the middle constriction, a role first described more than 30 years ago. However, while some partial data have been obtained regarding the formation of this gut constriction, an overall picture of the process is lacking. Here we unveil that Wg signalling leads to this constriction by inducing ClC-a transcription in a subset of mesodermal cells. ClC-a, encodes a chloride channel, which in turn prompts a Ca+2 pulse in these cells. Consequently, the mesoderm cells, which already showed some polarity, repolarise and in so doing so they reshape the microtubule organisation, therefore inducing the constriction of the cells.
Note: https://doi.org/10.1038/s44319-025-00411-x
It is part of: Embo Reports, 2025, 26, 1737 -1748
URI: https://hdl.handle.net/2445/222024
Related resource: https://doi.org/10.1038/s44319-025-00411-x
ISSN: Ricolo, D; Tamba, F; Casanova, J (2025). Autocrine Wingless constricts the Drosophila embryonic gut by Ca+2-mediated repolarisation of mesoderm cells. Embo Reports, (26), 1737 -1748. DOI: 10.1038/s44319-025-00411-x
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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