Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222035
Title: Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients
Author: Casadevall, Carme
Agranovich, Bella
Enríquez Rodríguez, Cesar Jesse
Faner, Rosa
Pascual-Guardia, Sergi
Castro Acosta, Ady Angélica
Camps Ubach, Ramon
García Aymerich, Judith
Barreiro, Esther
Monsó, Eduard
Seijo Maceiras, Luis Miguel
Soler Cataluña, Juan José
Santos Pérez, Salud
Peces Barba, Germán
López Campos, José Luis
Casanova, Ciro
Agustí García-Navarro, Àlvar
García Cosío, Borja
Abramovich, Ifat
Gea Guiral, Joaquim
EARLY COPD group
BIOMEPOC group
Keywords: Malalties pulmonars obstructives cròniques
Bioquímica clínica
Chronic obstructive pulmonary diseases
Clinical biochemistry
Issue Date: 9-May-2025
Publisher: MDPI
Abstract: The analysis of blood metabolites may help identify individuals at risk of having COPD and offer insights into its underlying pathophysiology. This study aimed to identify COPD-related metabolic alterations and generate a biological signature potentially useful for screening purposes. Plasma metabolomic profiles from 91 COPD patients and 91 controls were obtained using complementary semi-targeted and untargeted LC-MS approaches. Univariate analysis identified metabolites with significant differences between groups, and enrichment analysis highlighted the most affected metabolic pathways. Multivariate analysis, including ROC curve assessment and machine learning algorithms, was applied to assess the discriminatory capacity of selected metabolites. After adjustment for major potential confounders, 56 metabolites showed significant differences between COPD patients and controls. The enrichment analysis revealed that COPD-associated metabolic alterations primarily involved lipid metabolism (especially fatty acids and acylcarnitines), followed by amino acid pathways and xenobiotics. A panel of 10 metabolites, mostly related to lipid metabolism, demonstrated high discriminatory performance for COPD (ROC-AUC: 0.916; 90.1% sensitivity and 89% specificity). These findings may contribute to improving screening strategies and a better understanding of COPD-related metabolic changes. However, our findings remain exploratory and should be interpreted with caution, needing further validation and mechanistic studies.
Note: Reproducció del document publicat a: https://doi.org/10.3390/ijms26104526
It is part of: International Journal of Molecular Sciences, 2025, vol. 26, num. 10
URI: https://hdl.handle.net/2445/222035
Related resource: https://doi.org/10.3390/ijms26104526
ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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