Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222129
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLópez Molina, Laura-
dc.contributor.authorSancho Balsells, Anna-
dc.contributor.authorAl-Massadi, Omar-
dc.contributor.authorMontalban, Enrica-
dc.contributor.authorAlberch i Vié, Jordi, 1959--
dc.contributor.authorArranz, Belém-
dc.contributor.authorGirault, Jean-Antoine-
dc.contributor.authorGiralt Torroella, Albert-
dc.date.accessioned2025-07-09T16:01:17Z-
dc.date.available2025-07-09T16:01:17Z-
dc.date.issued2024-03-27-
dc.identifier.issn0969-9961-
dc.identifier.urihttps://hdl.handle.net/2445/222129-
dc.description.abstractPyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntington's disease, and Alzheimer's disease. All these disorders are accompanied by different types of impairments in sociability, which has recently been linked to improper mitochondrial function. We hypothesize that Pyk2, which regulates mitochondria, could be associated with the regulation of mitochondrial dynamics and social skills. In the present manuscript, we report that a reduction of Pyk2 levels in mouse pyramidal neurons of the hippocampus decreased social dominance and aggressivity. Furthermore, social interactions induced robust Pyk2-dependent hippocampal changes in several oxidative phosphorylation complexes. We also observed that Pyk2 levels were increased in the CA1 pyramidal neurons of schizophrenic subjects, occurring alongside changes in different direct and indirect regulators of mitochondrial function including DISC1 and Grp75. Accordingly, overexpressing Pyk2 in hippocampal CA1 pyramidal cells mimicked some specific schizophrenia-like social behaviors in mice. In summary, our results indicate that Pyk2 might play a role in regulating specific social skills likely via mitochondrial dynamics and that there might be a link between Pyk2 levels in hippocampal neurons and social disturbances in schizophrenia.-
dc.format.extent14 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.nbd.2024.106487-
dc.relation.ispartofNeurobiology of Disease, 2024, num.194-
dc.relation.urihttps://doi.org/10.1016/j.nbd.2024.106487-
dc.rightscc-by-nc-nd (c) Elsevier, 2024-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceArticles publicats en revistes (Biomedicina)-
dc.subject.classificationHipocamp (Cervell)-
dc.subject.classificationManifestacions neurològiques de les malalties-
dc.subject.classificationPsicosi-
dc.subject.classificationMetabolisme-
dc.subject.otherHippocampus (Brain)-
dc.subject.otherNeurologic manifestations of general diseases-
dc.subject.otherPsychoses-
dc.subject.otherMetabolism-
dc.titleHippocampal Pyk2 regulates specific social skills: Implications for schizophrenia-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec753677-
dc.date.updated2025-07-09T16:01:17Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid38552722-
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
876680.pdf9.95 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons