Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222217
Title: The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC
Author: Peduzzi, Giulia
Archibugi, Livia
Farinella, Riccardo
Leon Pisani, Ruggero Ponz de
Vodičková, Ludmila
Vodička, Pavel
Kraja, Bledar
Sainz Pérez, Juan
Bars Cortina, David
Daniel, Neil
Silvestri, Roberto
Uysal Onganer, Pinar
Landi, Stefano
Dulińska Litewka, Joanna
Comandatore, Annalisa
Campa, Daniele
Hughes, David J.
Rizzato, Cosmeri
Keywords: Càncer de pàncrees
Factors de risc en les malalties
Avaluació del risc per la salut
Pancreas cancer
Risk factors in diseases
Health risk assessment
Issue Date: 12-May-2025
Publisher: Elsevier BV
Abstract: Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3 % of cancer diagnoses, causes 7 % of cancer deaths due to its severity and asymptomatic early stages. Risk factors include lifestyle choices, environmental exposures, and genetic predispositions. Conditions like new-onset type 2 diabetes and chronic pancreatitis also contribute significantly. Modifiable risk factors include smoking, alcohol consumption, non-alcoholic fatty pancreatic disease (NAFPD), and obesity. Smoking and heavy alcohol consumption increase PC risk, while NAFPD and obesity, particularly central adiposity, contribute through chronic inflammation and insulin resistance. Refined sugar and sugar-sweetened beverages (SSBs) are also linked to increased PC risk, especially among younger individuals. Hormonal treatments and medications like statins, aspirin, and metformin have mixed results on PC risk, with some showing protective effects. The gut microbiome influences PC through the gut-pancreas axis, with disruptions leading to inflammation and carcinogenesis. Exposure to toxic substances, including heavy metals and chemicals, is associated with increased PC risk. Glycome changes, such as abnormal glycosylation patterns, are significant in PDAC development and offer potential for early diagnosis. Interactions between environmental and genetic factors are crucial in PDAC susceptibility. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) linked to PDAC, but gene-environment interactions remain largely unexplored. Future research should focus on polygenic risk scores (PRS) and large-scale studies to better understand these interactions and their impact on PDAC risk.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.semcancer.2025.05.004
It is part of: Seminars in Cancer Biology, 2025, vol. 113, p. 100-129
URI: https://hdl.handle.net/2445/222217
Related resource: https://doi.org/10.1016/j.semcancer.2025.05.004
ISSN: 1044-579X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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