Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222249
Title: Altered resting-state functional connectivity in individuals at risk for Alzheimer’s disease: a longitudinal study
Author: Chavarría Elizondo, Pamela
Maturana Quijada, Pablo Andrés
Martínez Zalacaín, Ignacio
Cerro San Ildefonso, Inés del
Juaneda Seguí, Asier
Guinea Izquierdo, Andrés
Gascón Bayarri, Jordi
Reñé Ramírez, Ramon
Urretavizcaya Sarachaga, Mikel
Ferrer, Isidro (Ferrer Abizanda)
Menchón Magriñá, José Manuel
Soria, Virginia
Soriano Mas, Carles
Keywords: Malaltia d'Alzheimer
Neurociència computacional
Alzheimer's disease
Computational neuroscience
Issue Date: 1-Apr-2025
Publisher: Elsevier BV
Abstract: Background: Resting-state functional connectivity magnetic resonance imaging (rs-fMRI) is a sensitive tool for detecting early brain changes associated with Alzheimer's disease, even in its preclinical stages. Amnestic mild cognitive impairment (aMCI) and late-life depression (LLD) are two prevalent conditions in older adults that significantly elevate the risk of cognitive decline and dementia. This study aimed to elucidate the underlying neurobiological substrates by longitudinally identifying and comparing distinct connectivity patterns in aMCI subjects and LLD patients, and by examining the associations between these patterns and clinical measures of cognitive and mood impairments. Methods: The study included three groups: 26 healthy controls (HCs), 15 individuals with aMCI, and 21 patients with LLD. All participants underwent rs-fMRI and neuropsychological assessments at baseline and at a 2-year follow-up. Functional connectivity was analyzed using a group Independent Component Analysis (ICA) model to investigate both group differences and longitudinal changes over time. Results: At baseline, individuals with aMCI exhibited reduced functional connectivity in the precuneus, whereas LLD patients showed decreased connectivity in frontal, insular, and postcentral regions alongside increased connectivity in posterior parietal and cuneal cortices. Correlation analyses revealed that lower baseline insular connectivity predicted higher depressive symptoms at follow-up in aMCI subjects. In LLD, reduced baseline precuneus connectivity was associated with better two-year outcomes in global cognition and long-term memory. Conclusions: This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with aMCI and LLD, underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.ijchp.2025.100588
It is part of: International Journal of Clinical and Health Psychology, 2025, vol. 25, num. 2, 100588
URI: https://hdl.handle.net/2445/222249
Related resource: https://doi.org/10.1016/j.ijchp.2025.100588
ISSN: 2174-0852
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)

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