Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222273
Title: Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
Author: Pinto Hernández, Paola
Fernández Sanjurjo, Manuel
Paget, Daan
Caravia, Xurde M.
Roiz Valle, David
Castilla Silgado, Juan
Diez Robles, Sergio
Coto Vilcapoma, Almudena
Fernández Vivero, David
Gama Pérez, Pau
García Roves, Pablo Miguel
López Otin, Carlos
Zierath, Juleen R.
Krook, Anna
Fernández García, Benjamin
Tomás Zapico, Cristina
Iglesias Gutierrez, Eduardo
Keywords: Fisiologia de l'exercici
Micro RNAs
Exercise physiology
MicroRNAs
Issue Date: 23-May-2025
Publisher: Elsevier BV
Abstract: Objective: The adaptive response to different models of regular exercise involves complex tissue crosstalk. Our aim was to explore the involvement of extracellular vesicle (EV) microRNAs (miRNAs) in this process, the secretory role of skeletal muscle and its functional metabolic interaction with the liver. Methods: Plasma EV miRNAs obtained from mice after 4-weeks of endurance or resistance training were sequenced. Subsequent experiments using trained genetically modified mouse models and in vitro approaches involving knock-down and electrostimulated cells, were conducted. Results: Resistance training increased the expression of a group of 11 miRNAs functionally divided into two clusters. Among them, miR-29a-3p emerges as a molecular mediator released in EVs by skeletal muscle, with a relevant role in adaptation to endurance training, by contributing to modulate the expression and secretion of other miRNAs associated with training and regulating processes related to substrate availability, transport, and metabolic use in skeletal muscle and liver. Conclusions: Our study suggests that miR-29a-3p is a training-induced molecular mediator in the response and adaptation to resistance training, possibly due to its regulatory role in energy metabolism in skeletal muscle in response to exercise. (c) 2025 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.molmet.2025.102173
It is part of: Molecular Metabolism, 2025, vol. 98, 102173
URI: https://hdl.handle.net/2445/222273
Related resource: https://doi.org/10.1016/j.molmet.2025.102173
ISSN: 2212-8778
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)

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