Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222285
Title: Adherence to the Mediterranean diet to prevent or delay hepatic steatosis: a longitudinal analysis within the PREDIMED study
Author: Cueto Galán, Raquel
Fontalba Navas, Andrés
Gutiérrez Bedmar, Mario
Ruiz Canela, Miguel
Martínez-González, Miguel Ángel, 1957-
Alves, Lilian
Babio, Nancy
Fitó Colomer, Montserrat
Ros Rahola, Emilio
Fiol Sala, Miguel
Estruch Riba, Ramon
Arós Borau, Luis Fernando
Serra Majem, Lluís
Pintó Sala, Xavier
Muñoz Bravo, Carlos
García Rodriguez, Antonio
Gómez Gracia, Enrique
Keywords: Cuina mediterrània
Malalties del fetge
Mediterranean cooking
Liver diseases
Issue Date: 21-May-2025
Publisher: Frontiers Media SA
Abstract: Background Little is known about the potential preventive effect of adherence to the Mediterranean diet (MedDiet) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD).Aim This study aims to determine the impact of adherence to the MedDiet on the progression of MASLD, measured using the hepatic steatosis index (HSI) at baseline and annually over a 5-year follow-up period within the framework of the PREvenci & oacute;n con DIeta MEDiterr & aacute;nea (PREDIMED) study.Method Participants from the PREDIMED trial with sufficient available data (n = 3,145) were examined annually over 5 years. Adherence to the MedDiet was evaluated using the Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and the presence/severity of hepatic steatosis was determined according to the HSI. Linear mixed models were used to analyze the association between the study variables and HSI.Results The participants (57% female, 43% male) had a mean age of 67.2 (SD 6.2) years. Among the cardiovascular risk factors considered, the mean BMI was 29.81 (SD 3.62); 47% of participants had type 2 diabetes, 70% had hypercholesterolaemia, and 84% had hypertension. Over the 5-year follow-up, average adherence to the MedDiet and physical activity generally increased, while alcohol consumption, calorie intake, tobacco use, hypercholesterolaemia, and hypertension decreased. The fully adjusted multivariate model reflected a statistically significant decrease in the HSI per unit increase in adherence to the MedDiet (beta = -0.075; 95% CI: -0.128, -0.021).Conclusion In individuals at high cardiovascular risk, adherence to the MedDiet is significantly associated with improvements in HSI. These longitudinal findings highlight the important role of the MedDiet in delaying or slowing the natural progression of MASLD, contributing to both its prevention and clinical management.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fnut.2025.1518082
It is part of: Frontiers in Nutrition, 2025, vol. 12
URI: https://hdl.handle.net/2445/222285
Related resource: https://doi.org/10.3389/fnut.2025.1518082
ISSN: 2296-861X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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