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https://hdl.handle.net/2445/222479
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DC Field | Value | Language |
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dc.contributor.author | Fernández, Alejandro | - |
dc.contributor.author | Gairí Tahull, Margarida | - |
dc.contributor.author | González, Maria Teresa | - |
dc.contributor.author | Pons Vallès, Miquel | - |
dc.date.accessioned | 2025-07-22T12:23:50Z | - |
dc.date.available | 2025-07-22T12:23:50Z | - |
dc.date.issued | 2024-11-08 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | https://hdl.handle.net/2445/222479 | - |
dc.description.abstract | Methionine residues within the kinase domain of Src serve as unique NMR probes capable of distinguishing between distinct conformational states of full-length Src, including alternative drug-inhibited forms. This approach offers a rapid method to differentiate between various inhibition mechanisms at any stage of drug development, eliminating the need to resolve the structure of Src-drug complexes. Using selectively 13C-methyl-enriched methionine, spectra can be acquired in under an hour, while natural abundance spectra with comparable information are achievable within a few hours. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/https://doi.org/10.1021/acs.jmedchem.4c02042 | - |
dc.relation.ispartof | Journal of Medicinal Chemistry, 2024, vol. 67, p. 20571-20579 | - |
dc.relation.uri | https://doi.org/https://doi.org/10.1021/acs.jmedchem.4c02042 | - |
dc.rights | cc-by (c) Fernández, Alejandro et al., 2024 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Monòmers | - |
dc.subject.classification | Pèptids | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Monomers | - |
dc.subject.other | Peptides | - |
dc.title | A fast method to monitor tyrosine kinase inhibitors mechanisms | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 757663 | - |
dc.date.updated | 2025-07-22T12:23:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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891092.pdf | 6.12 MB | Adobe PDF | View/Open |
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