Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222479
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dc.contributor.authorFernández, Alejandro-
dc.contributor.authorGairí Tahull, Margarida-
dc.contributor.authorGonzález, Maria Teresa-
dc.contributor.authorPons Vallès, Miquel-
dc.date.accessioned2025-07-22T12:23:50Z-
dc.date.available2025-07-22T12:23:50Z-
dc.date.issued2024-11-08-
dc.identifier.issn0022-2623-
dc.identifier.urihttps://hdl.handle.net/2445/222479-
dc.description.abstractMethionine residues within the kinase domain of Src serve as unique NMR probes capable of distinguishing between distinct conformational states of full-length Src, including alternative drug-inhibited forms. This approach offers a rapid method to differentiate between various inhibition mechanisms at any stage of drug development, eliminating the need to resolve the structure of Src-drug complexes. Using selectively 13C-methyl-enriched methionine, spectra can be acquired in under an hour, while natural abundance spectra with comparable information are achievable within a few hours.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/https://doi.org/10.1021/acs.jmedchem.4c02042-
dc.relation.ispartofJournal of Medicinal Chemistry, 2024, vol. 67, p. 20571-20579-
dc.relation.urihttps://doi.org/https://doi.org/10.1021/acs.jmedchem.4c02042-
dc.rightscc-by (c) Fernández, Alejandro et al., 2024-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationBiologia molecular-
dc.subject.classificationMonòmers-
dc.subject.classificationPèptids-
dc.subject.otherMolecular biology-
dc.subject.otherMonomers-
dc.subject.otherPeptides-
dc.titleA fast method to monitor tyrosine kinase inhibitors mechanisms-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec757663-
dc.date.updated2025-07-22T12:23:50Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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