Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222714
Title: Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review
Author: Kasapgil, Esra
Garay-Sarmiento, Manuela
Rodriguez-Emmenegger, César
Keywords: Bioengineering
Biomedical engineering
Biotecnología
Farmacia
Materiais
Medicine (miscellaneous)
Medicine, research & experimental
Nanoscience and nanotechnology
Odontología
Animals
Anti-bacterial agents
Antifouling coatings
Antimicrobial peptide
Antimicrobial-eluting coatings
Bacterial adhesion
Bacterial biofilm formation
Biocompatible materials
Biofilms
Biomaterial-associated infections
Contact killing coatings
Humans
In-vitr
Infused porous surfaces
Metal-oxide surfaces
Multifunctional antimicrobial coating
Multifunctional antimicrobial coatings
Poly(l-lysine)-g-poly(ethylene glycol) layers
Polymer brushes
Prosthesis-related infections
Silicone oil
Superhydrophobic surfaces
Urinary catheters
Issue Date: 1-Nov-2024
Citation: Kasapgil, E; Garay-Sarmiento, M; Rodriguez-Emmenegger, C (2024). Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review. Wiley Interdisciplinary Reviews-Nanomedicine And Nanobiotechnology, 16(6), e2018-. DOI: 10.1002/wnan.2018
Abstract: Biomaterial-associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in-depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial-eluting biomaterials, contact-killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology.
Note: https://doi.org/10.1002/wnan.2018
It is part of: Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2024, 16, 6, e2018
URI: https://hdl.handle.net/2445/222714
Related resource: https://doi.org/10.1002/wnan.2018
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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