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https://hdl.handle.net/2445/222714
Title: | Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review |
Author: | Kasapgil, Esra Garay-Sarmiento, Manuela Rodriguez-Emmenegger, César |
Keywords: | Bioengineering Biomedical engineering Biotecnología Farmacia Materiais Medicine (miscellaneous) Medicine, research & experimental Nanoscience and nanotechnology Odontología Animals Anti-bacterial agents Antifouling coatings Antimicrobial peptide Antimicrobial-eluting coatings Bacterial adhesion Bacterial biofilm formation Biocompatible materials Biofilms Biomaterial-associated infections Contact killing coatings Humans In-vitr Infused porous surfaces Metal-oxide surfaces Multifunctional antimicrobial coating Multifunctional antimicrobial coatings Poly(l-lysine)-g-poly(ethylene glycol) layers Polymer brushes Prosthesis-related infections Silicone oil Superhydrophobic surfaces Urinary catheters |
Issue Date: | 1-Nov-2024 |
Citation: | Kasapgil, E; Garay-Sarmiento, M; Rodriguez-Emmenegger, C (2024). Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review. Wiley Interdisciplinary Reviews-Nanomedicine And Nanobiotechnology, 16(6), e2018-. DOI: 10.1002/wnan.2018 |
Abstract: | Biomaterial-associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in-depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial-eluting biomaterials, contact-killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology. |
Note: | https://doi.org/10.1002/wnan.2018 |
It is part of: | Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2024, 16, 6, e2018 |
URI: | https://hdl.handle.net/2445/222714 |
Related resource: | https://doi.org/10.1002/wnan.2018 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2024_WIRENanNan_Advanced_RodriguezEmmeneggerC.pdf | 11.09 MB | Adobe PDF | View/Open |
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