Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/222728
Title: | Synthesis of the ABC Core of Daphniphyllum Alkaloids with a [5-6-7] Azatricyclic Scaffold via Ring Expansion of Azabicyclic and Azatricyclic Building Blocks |
Author: | Marquès, Clàudia González-Lizana, David Diaba, Faïza Bonjoch i Sesé, Jose |
Keywords: | Mescles Compostos orgànics Cetones Mixtures Organic compounds Ketones |
Issue Date: | 19-Jul-2024 |
Publisher: | American Chemical Society |
Abstract: | The [5–6–7] azatricyclic ABC core, found in several Daphniphyllum alkaloids, has been synthesized through a novel route involving ring expansion of a perhydroindolone to afford the AC ring system and a radical B ring closure as key steps. The level of functionalization of the reported octahydro-1,7-ethanocyclohepta[b]pyrroles suggests that they can serve as valuable building blocks in this alkaloid field. Also reported is the first synthesis of homomorphans by the ring enlargement of 2-azabicyclo[3.3.1]nonanes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.joc.4c01090 |
It is part of: | Journal of Organic Chemistry, 2024, vol. 89, num.14, p. 10212-10222 |
URI: | https://hdl.handle.net/2445/222728 |
Related resource: | https://doi.org/10.1021/acs.joc.4c01090 |
ISSN: | 0022-3263 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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866482.pdf | 2.23 MB | Adobe PDF | View/Open |
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