Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222728
Title: Synthesis of the ABC Core of Daphniphyllum Alkaloids with a [5-6-7] Azatricyclic Scaffold via Ring Expansion of Azabicyclic and Azatricyclic Building Blocks
Author: Marquès, Clàudia
González-Lizana, David
Diaba, Faïza
Bonjoch i Sesé, Jose
Keywords: Mescles
Compostos orgànics
Cetones
Mixtures
Organic compounds
Ketones
Issue Date: 19-Jul-2024
Publisher: American Chemical Society
Abstract: The [5–6–7] azatricyclic ABC core, found in several Daphniphyllum alkaloids, has been synthesized through a novel route involving ring expansion of a perhydroindolone to afford the AC ring system and a radical B ring closure as key steps. The level of functionalization of the reported octahydro-1,7-ethanocyclohepta[b]pyrroles suggests that they can serve as valuable building blocks in this alkaloid field. Also reported is the first synthesis of homomorphans by the ring enlargement of 2-azabicyclo[3.3.1]nonanes.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/acs.joc.4c01090
It is part of: Journal of Organic Chemistry, 2024, vol. 89, num.14, p. 10212-10222
URI: https://hdl.handle.net/2445/222728
Related resource: https://doi.org/10.1021/acs.joc.4c01090
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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