Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222846
Full metadata record
DC FieldValueLanguage
dc.contributor.authorA. Katzke, Verena-
dc.contributor.authorDutta, Srimanti-
dc.contributor.authorRasokat, Anna-
dc.contributor.authorArchibugi, Livia-
dc.contributor.authorCapurso, Gabriele-
dc.contributor.authorPeduzzi, Giulia-
dc.contributor.authorGentiluomo, Manuel-
dc.contributor.authorCanzian, Federico-
dc.contributor.authorKirstine Eriksen, Anne-
dc.contributor.authorTjønneland, Anne-
dc.contributor.authorC. Dahm, Christina-
dc.contributor.authorTruong, Therese-
dc.contributor.authorCanonico, Marianne-
dc.contributor.authorLaouali, Nasser-
dc.contributor.authorB. Schulze, Matthias-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorMasala, Giovanna-
dc.contributor.authorAgnoli, Claudia-
dc.contributor.authorDansero, Lucia-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorCrous-bou, Marta-
dc.contributor.authorMolina-montes, Esther-
dc.contributor.authorDorronsoro, Ane-
dc.contributor.authorChirlaque, María-dolores-
dc.contributor.authorGuevara, Marcela-
dc.contributor.authorTunå Butt, Salma-
dc.contributor.authorSund, Malin-
dc.contributor.authorChristakoudi, Sofia-
dc.contributor.authorK. Aglago, Elom-
dc.contributor.authorWeiderpass, Elisabete-
dc.contributor.authorGunter, Marc-
dc.contributor.authorCampa, Daniele-
dc.contributor.authorKaaks, Rudolf-
dc.date.accessioned2025-08-29T12:07:49Z-
dc.date.available2025-08-29T12:07:49Z-
dc.date.issued2025-07-08-
dc.identifier.urihttps://hdl.handle.net/2445/222846-
dc.description.abstractBackground/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to <= 5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus <= 2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI AG-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cancers17142275-
dc.relation.ispartofCancers, 2025, vol. 17, issue. 14, p. 2275-
dc.relation.urihttps://doi.org/10.3390/cancers17142275-
dc.titleSex Disparities and Female Reproductive and Hormonal Factors Associated with Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort-
dc.typeinfo:eu-repo/semantics/article-
dc.date.updated2025-08-26T12:52:28Z-
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
cancers-17-02275-v2.pdf422.54 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.