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https://hdl.handle.net/2445/222846
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DC Field | Value | Language |
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dc.contributor.author | A. Katzke, Verena | - |
dc.contributor.author | Dutta, Srimanti | - |
dc.contributor.author | Rasokat, Anna | - |
dc.contributor.author | Archibugi, Livia | - |
dc.contributor.author | Capurso, Gabriele | - |
dc.contributor.author | Peduzzi, Giulia | - |
dc.contributor.author | Gentiluomo, Manuel | - |
dc.contributor.author | Canzian, Federico | - |
dc.contributor.author | Kirstine Eriksen, Anne | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | C. Dahm, Christina | - |
dc.contributor.author | Truong, Therese | - |
dc.contributor.author | Canonico, Marianne | - |
dc.contributor.author | Laouali, Nasser | - |
dc.contributor.author | B. Schulze, Matthias | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Masala, Giovanna | - |
dc.contributor.author | Agnoli, Claudia | - |
dc.contributor.author | Dansero, Lucia | - |
dc.contributor.author | Panico, Salvatore | - |
dc.contributor.author | Crous-bou, Marta | - |
dc.contributor.author | Molina-montes, Esther | - |
dc.contributor.author | Dorronsoro, Ane | - |
dc.contributor.author | Chirlaque, María-dolores | - |
dc.contributor.author | Guevara, Marcela | - |
dc.contributor.author | Tunå Butt, Salma | - |
dc.contributor.author | Sund, Malin | - |
dc.contributor.author | Christakoudi, Sofia | - |
dc.contributor.author | K. Aglago, Elom | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Gunter, Marc | - |
dc.contributor.author | Campa, Daniele | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.date.accessioned | 2025-08-29T12:07:49Z | - |
dc.date.available | 2025-08-29T12:07:49Z | - |
dc.date.issued | 2025-07-08 | - |
dc.identifier.uri | https://hdl.handle.net/2445/222846 | - |
dc.description.abstract | Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to <= 5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus <= 2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers17142275 | - |
dc.relation.ispartof | Cancers, 2025, vol. 17, issue. 14, p. 2275 | - |
dc.relation.uri | https://doi.org/10.3390/cancers17142275 | - |
dc.title | Sex Disparities and Female Reproductive and Hormonal Factors Associated with Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2025-08-26T12:52:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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cancers-17-02275-v2.pdf | 422.54 kB | Adobe PDF | View/Open |
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