Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222857
Title: Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator
Author: Romero Obon, Miquel
Sancho-Ochoa, Virginia
Rouaz El Hajoui, Khadija
Pérez Lozano, Pilar
Suñé Pou, Marc
Suñé i Negre, Josep M. (Josep Maria)
García Montoya, Encarna
Keywords: Disseny d'experiments
Farmàcia clínica
Experimental design
Clinical pharmacy
Issue Date: 1-Jul-2025
Publisher: MDPI
Abstract: This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi– Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry. QbD is a systematic, proactive methodology that integrates quality considerations throughout the product lifecycle to ensure that pharmaceutical products meet regulatory standards for safety and efficacy from the outset of development. The Pi–Buckingham theorem serves as a foundational principle in dimensional analysis, facilitating the simplification of complex models by transforming physical variables into dimensionless parameters. This synergy enables researchers to better understand and control the factors affecting critical quality attributes (CQAs), thereby improving manufacturing outcomes and minimizing variability. Keywords: Quality by Design; design space; Pi–Buckingham; dimensional analysis; design of experiments; pharmaceutical process development
Note: Reproducció del document publicat a: https://doi.org/10.3390/ph18071033
It is part of: Pharmaceuticals, 2025, vol. 18, num.7
URI: https://hdl.handle.net/2445/222857
Related resource: https://doi.org/10.3390/ph18071033
ISSN: 1424-8247
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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