Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222861
Title: Repurposing chemotherapy‐induced peripheral neuropathy grading
Author: Velasco, Roser
A. Argyriou, Andreas
R. Cornblath, David
Bruna, Pere
Alberti, Paola
Rossi, Emanuela
S. J. Merkies, Ingemar
Psimaras, Dimitri
Briani, Chiara
I. Lalisang, Roy
Schenone, Angelo
Cavaletti, Guido
Bruna, Jordi
Group, Ci‐perinoms
Issue Date: 16-Sep-2024
Publisher: Wiley
Abstract: Background and Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is per-ceived differently by patients and physicians, complicating its assessment. Current rec-ommendations advocate combining clinical and patient- reported outcomes measures, but this approach can be challenging in patient care. This multicenter European study aims to bridge the gap between patients' perceptions and neurological impairments by aligning both perspectives to improve treatment decision- making. Methods: Data were pooled from two prospective studies of subjects (n= 372) with established CIPN. Patient and physician views regarding CIPN were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI- CTCAE), Total Neuropathy Scale-clinical version (TNSc) items, and the disease-specific quality of life - Chemotherapy-Induced Peripheral Neuropathy questionnaire (QLQ- CIPN20) from the European Organization for Research and Treatment of Cancer (EORTC). To identiinherent neurotoxic severity patterns, we employed hierarchical cluster analysis opti-mized with k- means clustering and internally validated by discriminant functional analysis. Results: Both NCI- CTCAE and TNSc demonstrated a significant difference in the distri-bution of severity grades in relation to QLQ- CIPN20 scores. However, a proportion of subjects with different neurotoxic severity grades exhibited overlapping QLQ- CIPN20 scores. We identified three distinct clusters classifying subjects as having severely im-paired, intermediately impaired, and mildly impaired CIPN based on TNSc and QLQ- CIPN20 scores. No differences in demographics, cancer type distribution, or class of drug received were observed. Conclusions: Our results confirm the heterogeneity in CIPN perception between patients and physicians and identify three well-differentiated subgroups of patients delineated by degree of CIPN impairment based on scores derived from TNSc and QLQ- CIPN20. A more refined assessment of CIPN could potentially be achieved using the calculator tool derived from the cluster equations in this study. This tool, which facilitates individual patient classification, requires prospective validation
Note: Reproducció del document publicat a: https://doi.org/10.1111/ene.16457
It is part of: European Journal of Neurology, 2024, vol. 31, issue. 12
URI: https://hdl.handle.net/2445/222861
Related resource: https://doi.org/10.1111/ene.16457
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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