Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222897
Title: Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
Author: Fares Otero, Natalia Elena
Verdolini, Norma
Melero, Helena
Andrés Camazón, Pablo
Vilajosana, Enric
Cavone, Vito
García Bueno, Borja
Rapado Castro, Marta
Izquierdo, Ana
Martín Hernández, David
Mola Cárdenes, Pablo
Leal Leturia, Itziar
Dompablo Tobar, Mónica
Ortiz Tallo, Ana
Martínez Gras, Isabel
Muñoz Sanjose, Ainoa
Loeck de Lapuerta, Carmen
Rodriguez Jimenez, Roberto
Díaz-Marsá, Marina
Bravo Ortiz, María Fe
Ibañez, Angela
Baca García, Enrique
Vieta i Pascual, Eduard, 1963-
Ayuso Mateos, José Luis
Malpica, Norberto
Arango López, Celso
Díaz Caneja, Covadonga M.
Radua, Joaquim
Keywords: Psicosi en els infants
Neuropsiquiatria pediàtrica
Psychoses in children
Pediatric neuropsychiatry
Issue Date: 16-Dec-2024
Publisher: Cambridge University Press (CUP)
Abstract: Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT. Results Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region. Conclusions Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis.
Note: Reproducció del document publicat a: https://doi.org/10.1017/S0033291724002393
It is part of: Psychological Medicine, 2024, vol. 54, num.16, p. 4561-4574
URI: https://hdl.handle.net/2445/222897
Related resource: https://doi.org/10.1017/S0033291724002393
ISSN: 0033-2917
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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