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Title: | Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
Author: | Fares Otero, Natalia Elena Verdolini, Norma Melero, Helena Andrés Camazón, Pablo Vilajosana, Enric Cavone, Vito García Bueno, Borja Rapado Castro, Marta Izquierdo, Ana Martín Hernández, David Mola Cárdenes, Pablo Leal Leturia, Itziar Dompablo Tobar, Mónica Ortiz Tallo, Ana Martínez Gras, Isabel Muñoz Sanjose, Ainoa Loeck de Lapuerta, Carmen Rodriguez Jimenez, Roberto Díaz-Marsá, Marina Bravo Ortiz, María Fe Ibañez, Angela Baca García, Enrique Vieta i Pascual, Eduard, 1963- Ayuso Mateos, José Luis Malpica, Norberto Arango López, Celso Díaz Caneja, Covadonga M. Radua, Joaquim |
Keywords: | Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry |
Issue Date: | 16-Dec-2024 |
Publisher: | Cambridge University Press (CUP) |
Abstract: | Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT. Results Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region. Conclusions Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1017/S0033291724002393 |
It is part of: | Psychological Medicine, 2024, vol. 54, num.16, p. 4561-4574 |
URI: | https://hdl.handle.net/2445/222897 |
Related resource: | https://doi.org/10.1017/S0033291724002393 |
ISSN: | 0033-2917 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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