Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222935
Title: Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
Author: Azizi, Juzaili
Joseph, Adrian
Contini, Claudia
Cecchin, Denis
Nyberg, Sophie
Ruiz-Perez, Lorena
Preston, Jane
Volpe, Giorgio
Battaglia, Giuseppe
Gaitzsch, Jens
Fullstone, Gavin
Tian, Xiaohe
Keywords: Barrera hematoencefàlica
Polímers
Quimiotaxi
Blood-brain barrier
Polymers
Chemotaxis
Issue Date: 2-Aug-2017
Publisher: American Association for the Advancement of Science
Abstract: In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or microswimmers, capable of mimicking biological locomotion and taxis. This active diffusion enables the engineering of complex operations that so far have not been possible at the micro- and nanoscale. One of the most promising tasks is the ability to engineer nanocarriers that can autonomously navigate within tissues and organs, accessing nearly every site of the human body guided by endogenous chemical gradients. We report a fully synthetic, organic, nanoscopic system that exhibits attractive chemotaxis driven by enzymatic conversion of glucose. We achieve this by encapsulating glucose oxidase alone or in combination with catalase into nanoscopic and biocompatible asymmetric polymer vesicles (known as polymersomes). We show that these vesicles self-propel in response to an external gradient of glucose by inducing a slip velocity on their surface, which makes them move in an extremely sensitive way toward higher-concentration regions. We finally demonstrate that the chemotactic behavior of these nanoswimmers, in combination with LRP-1 (low-density lipoprotein receptor–related protein 1) targeting, enables a fourfold increase in penetration to the brain compared to nonchemotactic systems.<span style="color:rgba( 0 , 0 , 0 , 0 )"> recent years, </span>
Note: Reproducció del document publicat a: https://doi.org/10.1126/sciadv.1700362
It is part of: Science Advances, 2017
URI: https://hdl.handle.net/2445/222935
Related resource: https://doi.org/10.1126/sciadv.1700362
Appears in Collections:Articles publicats en revistes (Física Aplicada)

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