Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222947
Title: Functional brain abnormalities in post COVID-19 condition and their relationship with cognition.
Author: Carreras Vidal, Lourdes
Pacheco Jaime, Laura
Ariza González, Mar
Cano, Neus
Garolera i Freixa, Maite
García Vicente, Carla
Roura, Ignacio
Capdevila Lacasa, Clara
Oltra González, Javier
Pardo, Jèssica
Martín Barceló, Cristina
Campabadal Delgado, Anna
Sala Llonch, Roser
Bargalló Alabart, Núria
Barrué, Cristian
Bejar, Javier
Cortés, Claudio Ulises
Junqué i Plaja, Carme, 1955-
NAUTILUS-Project Collaborative Group
Segura i Fàbregas, Bàrbara
Keywords: Trastorns de la cognició
COVID-19
Cognition disorders
COVID-19
Issue Date: 1-Jul-2025
Publisher: Nature Publishing Group
Abstract: After COVID-19 infection, some patients develop a post-COVID condition (PCC) that is popularly referred to as long COVID. Among its symptoms is persistent cognitive dysfunction that is potentially linked to altered brain functional connectivity (FC). While research has explored functional reorganization in patients with PCC, the intra- and inter- network connectivity and its relationship with cognitive status and clinical outcomes remain unclear. In this study, we recruited 121 individuals with PCC (67 with, and 54 without, cognitive impairment), 20 months after infection, along with 37 non-infected healthy controls from the NAUTILUS Project (ClinicalTrials.gov IDs: NCT05307549 and NCT05307575). Participants underwent resting-state functional magnetic resonance imaging and comprehensive neuropsychological assessment. Resting-state networks were characterized using independent component analyses, dual regression and network modelling for individual FC characterization. Group differences in intra- and inter-network FC, and their associations with clinical and neuropsychological data, were studied. Significance was set at a corrected p-value of < 0.05. Patients with PCC showed increased intra-network FC in 10 cognitively relevant networks, including the default mode, salience, executive control, auditory and basal ganglia networks, correlating positively with general cognition (Montreal Cognitive Assessment scores), time since infection, fatigue and subjective memory failures. Increased inter-network FC between default mode and sensorimotor networks was also observed. Increases in FC may reflect an inefficient compensatory mechanism in patients with PCC, associated with fatigue, subjective memory complaints and persistence of PCC.   
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-025-00739-3
It is part of: Scientific Reports, 2025, vol. 15
URI: https://hdl.handle.net/2445/222947
Related resource: https://doi.org/10.1038/s41598-025-00739-3
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)

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