Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222967
Title: Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms
Author: Luo, Lin
Lechuga Vieco, Ana Victoria
Sattentau, Clara
Borsa, Mariana
Simon, Anna Katharina
Keywords: Cèl·lules T
Mitocondris
T cells
Mitochondria
Issue Date: 29-Aug-2025
Publisher: EMBO Press
Abstract: Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitochondrial dynamics, and inefficient removal of dysfunctional mitochondria. Both cell-intrinsic and cell-extrinsic mechanisms for removing mitochondria and their byproducts have been identified in T cells. In this review, we explore how T cells manage mitochondrial damage through changes in mitochondrial metabolism, mitophagy, asymmetric mitochondrial inheritance, and mitochondrial transfer, highlighting the impact of these mechanisms on T cell ageing and overall organismal ageing. We also discuss current therapeutic strategies aimed at removing dysfunctional mitochondria and their byproducts and propose potential new therapeutic targets that may reverse immune ageing or organismal ageing.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s44319-025-00536-z
It is part of: Embo Reports, 2025
URI: https://hdl.handle.net/2445/222967
Related resource: https://doi.org/10.1038/s44319-025-00536-z
ISSN: 1469-3178
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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