Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223048
Title: Life’s Simple 7 and Risk of Peripheral Artery Disease: Results from the PREDIMED Study and an Updated Meta-Analysis
Author: López Laguna, Nieves
Toledo Atucha, Estefanía
Hershey, María S.
Babio, Nancy
Sorlí, José V.
Ros Rahola, Emilio
Muñoz, Miguel Ángel
Estruch Riba, Ramon
Lapetra, José
Muñoz Bravo, Carlos
Fiol Sala, Miguel
Bautista Castaño, Inmaculada
Pintó Sala, Xavier
Ortega Azorín, Carolina
Hernando Redondo, Javier
Salas Salvadó, Jordi
Tojal Sierra, Lucas
Martínez-González, Miguel Ángel, 1957-
Ruiz Canela, Miguel
Keywords: Malalties cardiovasculars
Assaigs clínics
Factors de risc en les malalties
Cuina mediterrània
Exercici terapèutic
Cardiovascular diseases
Clinical trials
Risk factors in diseases
Mediterranean cooking
Exercise therapy
Issue Date: 20-Jun-2025
Publisher: MDPI
Abstract: Background: Peripheral artery disease (PAD) is a major vascular condition often overlooked in prevention strategies. We aimed to evaluate the association between cardiovascular health, measured by Life's Simple 7 (LS7), and the risk of PAD in a high-risk Mediterranean population. Methods: This prospective analysis included 7122 participants from the PREDIMED study (Prevención con Dieta Mediterránea) at high cardiovascular risk but free of cardiovascular disease at baseline. LS7 scores (0-14 points) were calculated using seven metrics: smoking status, body mass index, physical activity, blood pressure, total cholesterol, glucose metabolism, and adherence to the Mediterranean diet. Participants were categorized into inadequate (0-5), average (6-8), and optimal (9-14) cardiovascular health. Multivariable Cox regression models and Nelson-Aalen curves assessed the association between LS7 and PAD incidence over a median 4.8-year follow-up. A meta-analysis combining these results with three prior studies was also performed. Results: A total of 87 incident PAD cases were identified. Compared to participants with inadequate cardiovascular health, those with average and optimal LS7 scores exhibited significantly lower PAD risk (adjusted hazard ratio [HR] 0.37; 95% confidence interval [CI]: 0.22-0.61, and HR 0.25; 95% CI: 0.10-0.65, respectively). Each one-point increase in the LS7 score (range 0 to 14) was associated with an 22% lower PAD risk (HR 0.78; 95% CI: 0.68-0.90). The meta-analysis yielded a pooled HR of 0.81 (95% CI: 0.76-0.87), confirming consistent inverse associations across populations. Conclusions: Greater adherence to LS7 metrics is associated with a significantly reduced risk of PAD in high-risk Mediterranean individuals. Promoting LS7 adherence may represent an effective strategy for preventing both cardiovascular disease and PAD.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nu17132058
It is part of: Nutrients, 2025, vol. 17, num.13
URI: https://hdl.handle.net/2445/223048
Related resource: https://doi.org/10.3390/nu17132058
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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