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https://hdl.handle.net/2445/223114
Title: | Patient Stratification for Serum LDH Levels Reveals Distinct CLA+ T-Cell Cytokine Secretion in Response to HDM, Clinical Features and Allergic Comorbidities |
Author: | García Jiménez, Irene Figueras Nart, Ignasi Sans de San Nicolás, Lídia Curto Barredo, Laia Bertolín Colilla, Marta Bonfill Ortí, Montserrat Díez Ribas, Sandra Llobet del Pino, Alex Guilabert Vidal, Antonio Ryzhkova, Anna Ferran, Marta Pujol, Ramon M. Santamaria Babí, Luis F. |
Keywords: | Al·lèrgia Dermatitis atòpica Allergy Atopic dermatitis |
Issue Date: | 13-Aug-2025 |
Publisher: | MDPI |
Abstract: | Lactate dehydrogenase (LDH) is a serum biomarker well known to correlate with disease severity in atopic dermatitis (AD). The aim of this study was to explore the cutaneous immune responses and the clinical profile of AD patients in relation to serum LDH levels. To this end, 47 untreated, adult patients with moderate-to-severe AD were stratified by median levels of serum LDH. Circulating memory T-cell responses to house dust mite (HDM) extract, in the presence of autologous lesional epidermal cells, were compared between AD subgroups. The LDHhigh group exhibited significantly higher IL-13, IL-5 and IL-9 in vitro responses confined to the cutaneous lymphocyte-associated antigen (CLA)+ subset compared to LDHlow patients. Clinically, LDHhigh patients were younger and exhibited more severe disease, elevated eosinophil counts in their blood, increased total and specific IgE levels in their plasma, and a higher prevalence of allergic rhinitis. Our data suggests that high LDH levels identify a subgroup of AD patients with a specific immune and clinical profile, and highlight the potential of LDH as a clinical parameter that may enable patient stratification for treatment selection. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms26167821 |
It is part of: | International Journal of Molecular Sciences, 2025, vol. 26, num. 16, 7821 |
URI: | https://hdl.handle.net/2445/223114 |
Related resource: | https://doi.org/10.3390/ijms26167821 |
ISSN: | 1422-0067 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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