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https://hdl.handle.net/2445/223265| Title: | Role of MITF in IgE and MRGPRX2-dependent mast cell activation |
| Author: | Guo, Yanru |
| Director/Tutor: | Martín Andorrà, Margarita |
| Keywords: | Immunologia Al·lèrgia Transducció de senyal cel·lular Anafilaxi Immunology Allergy Cellular signal transduction Anaphylaxis |
| Issue Date: | 20-Jul-2023 |
| Publisher: | Universitat de Barcelona |
| Abstract: | [eng] Anaphylaxis is a severe allergic reaction triggered by allergens to certain foods, medicines, insect venom, and other substances. Anaphylactic shock can be fatal if not treated. Mast cells are the effector cells in anaphylaxis, and mast cell transcriptional factors are crucial in controlling the production of mediators. In summary, this thesis shows the relevance of microphthalmia associatedtranscription factor (MITF) in IgE and MRGPRX2-dependent mast cell activation. Thus, MITF and MITF-dependent genes may become targets to treat IgE or MRGPRX2-dependent pathologies. |
| URI: | https://hdl.handle.net/2445/223265 |
| Appears in Collections: | Tesis Doctorals - Departament - Biomedicina |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| YG_PhD_THESIS.pdf | 32.57 MB | Adobe PDF | View/Open |
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