Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223537
Title: Neural correlates of human fear conditioning and sources of variability in 2199 individuals
Author: Radua, Joaquim
Savage, Hannah S.
Vilajosana, Enric
Jamieson, Alec
Abler, Birgit
Åhs, Fredrik
Beckers, Tom
Cardoner, N. (Narcís)
Cisler, Josh M.
Diniz, Juliana B.
Bach, Dominik R.
Elsenbruch, Sigrid
Greening, Steven G.
Holt, Daphne J.
Kaczkurkin, Antonia N.
Keil, Andreas
Kindt, Merel
Koch, Kathrin
LaBar, Kevin S.
Lam, Charlene L.
Larson, Christine L.
Lonsdorf, Tina B.
Merz, Christian J.
McLaughlin, Katie A.
Neria, Yuval
Pine, Daniel S.
Reekum, Carien M. van
Shackman, Alexander J.
Soriano Mas, Carles
Spoormaker, Victor I.
Stout, Daniel M.
Straube, Benjamin
Straube, Thomas
Tuominen, Lauri
Visser, Renée M.
Ahumada, Laura
Arolt, Volker
Batistuzzo, Marcelo C.
Bazán, Paulo R.
Biggs, Emma E.
Cano Català, Marta
Chavarría-Elizondo, Pamela
Cooper, Samuel E.
Dannlowski, Udo
Peña Arteaga, Víctor de la
DeCross, Stephanie N.
Domschke, Katharina
Ehlers, Mana R.
Graner, John L.
Hamm, Alfons O.
Herrmann, Martin J.
Huggins, Ashley A.
Icenhour, Adriane
Juaneda Seguí, Asier
Junghoefer, Markus
Kircher, Tilo
Koelkebeck, Katja
Kuhn, Manuel
Labrenz, Franziska
Lissek, Shmuel M.
Lotze, Martin
Lueken, Ulrike
Margraf, Jürgen
Martínez Zalacaín, Ignacio
Moeck, Robert
Morriss, Jayne
Ortuño, María
Pittig, Andre
Porta Casteràs, Daniel
Richter, Jan
Ridderbusch, Isabelle C.
Rief, Winfried
Roesmann, Kati
Rosén, Jörgen
Rußmann, Alena N.
Sjouwerman, Rachel
Spohrs, Jennifer
Ströhle, Andreas
Suárez Jimenez, Benjamin
Ulrich, Martin
Wittchen, Hans-Ulrich
Zhu, Xi
Waller, Lea
Walter, Henrik
Thompson, Paul M.
Bas Hoogendam, Janna Marie
Groenewold, Nynke A.
Stein, Dan J., 1962-
Van der Wee, N.J.
Dunsmoor, Joseph E.
Marquand, Andre
Harrison, Ben J.
Fullana Rivas, Miguel Àngel
Keywords: Neurociència computacional
Neuropsiquiatria
Neurociència cognitiva
Computational neuroscience
Neuropsychiatry
Cognitive neuroscience
Issue Date: 23-Aug-2025
Publisher: Nature Publishing Group
Abstract: Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the “central autonomic–interoceptive” or “salience” network. Several task variables strongly modulate activity in these regions, contributing to variability in neural responses. Additionally, brain activation patterns differ between healthy individuals and those with anxiety-related or depressive disorders, with distinct profiles characterizing specific disorders such as post-traumatic stress disorder and obsessive-compulsive disorder. While the neural correlates of fear conditioning are highly generalizable at the population level, variability arises from differences in task design and clinical status, highlighting the importance of methodological diversity in capturing fear learning mechanisms
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-025-63078-x
It is part of: Nature Communications, 2025, vol. 16, 7869
URI: https://hdl.handle.net/2445/223537
Related resource: https://doi.org/10.1038/s41467-025-63078-x
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Ciències Clíniques)

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