Title: | Neural correlates of human fear conditioning and sources of variability in 2199 individuals |
Author: | Radua, Joaquim Savage, Hannah S. Vilajosana, Enric Jamieson, Alec Abler, Birgit Åhs, Fredrik Beckers, Tom Cardoner, N. (Narcís) Cisler, Josh M. Diniz, Juliana B. Bach, Dominik R. Elsenbruch, Sigrid Greening, Steven G. Holt, Daphne J. Kaczkurkin, Antonia N. Keil, Andreas Kindt, Merel Koch, Kathrin LaBar, Kevin S. Lam, Charlene L. Larson, Christine L. Lonsdorf, Tina B. Merz, Christian J. McLaughlin, Katie A. Neria, Yuval Pine, Daniel S. Reekum, Carien M. van Shackman, Alexander J. Soriano Mas, Carles Spoormaker, Victor I. Stout, Daniel M. Straube, Benjamin Straube, Thomas Tuominen, Lauri Visser, Renée M. Ahumada, Laura Arolt, Volker Batistuzzo, Marcelo C. Bazán, Paulo R. Biggs, Emma E. Cano Català, Marta Chavarría-Elizondo, Pamela Cooper, Samuel E. Dannlowski, Udo Peña Arteaga, Víctor de la DeCross, Stephanie N. Domschke, Katharina Ehlers, Mana R. Graner, John L. Hamm, Alfons O. Herrmann, Martin J. Huggins, Ashley A. Icenhour, Adriane Juaneda Seguí, Asier Junghoefer, Markus Kircher, Tilo Koelkebeck, Katja Kuhn, Manuel Labrenz, Franziska Lissek, Shmuel M. Lotze, Martin Lueken, Ulrike Margraf, Jürgen Martínez Zalacaín, Ignacio Moeck, Robert Morriss, Jayne Ortuño, María Pittig, Andre Porta Casteràs, Daniel Richter, Jan Ridderbusch, Isabelle C. Rief, Winfried Roesmann, Kati Rosén, Jörgen Rußmann, Alena N. Sjouwerman, Rachel Spohrs, Jennifer Ströhle, Andreas Suárez Jimenez, Benjamin Ulrich, Martin Wittchen, Hans-Ulrich Zhu, Xi Waller, Lea Walter, Henrik Thompson, Paul M. Bas Hoogendam, Janna Marie Groenewold, Nynke A. Stein, Dan J., 1962- Van der Wee, N.J. Dunsmoor, Joseph E. Marquand, Andre Harrison, Ben J. Fullana Rivas, Miguel Àngel |
Keywords: | Neurociència computacional Neuropsiquiatria Neurociència cognitiva Computational neuroscience Neuropsychiatry Cognitive neuroscience |
Issue Date: | 23-Aug-2025 |
Publisher: | Nature Publishing Group |
Abstract: | Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the “central autonomic–interoceptive” or “salience” network. Several task variables strongly modulate activity in these regions, contributing to variability in neural responses. Additionally, brain activation patterns differ between healthy individuals and those with anxiety-related or depressive disorders, with distinct profiles characterizing specific disorders such as post-traumatic stress disorder and obsessive-compulsive disorder. While the neural correlates of fear conditioning are highly generalizable at the population level, variability arises from differences in task design and clinical status, highlighting the importance of methodological diversity in capturing fear learning mechanisms |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-025-63078-x |
It is part of: | Nature Communications, 2025, vol. 16, 7869 |
URI: | https://hdl.handle.net/2445/223537 |
Related resource: | https://doi.org/10.1038/s41467-025-63078-x |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Ciències Clíniques)
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