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Title: Synovial fluid examination for the diagnosis of synovial amyloidosis in patients with chronic renal failure undergoing haemodialysis
Author: Muñoz Gómez, José
Gómez-Pérez, R.
Solé Arqués, Manuel
Llopart-Buisán, E.
Keywords: Amiloïdosi
Insuficiència renal crònica
Chronic renal failure
Issue Date: 1987
Publisher: BMJ Group
Abstract: The diagnosis of synovial amyloidosis is based upon synovial biopsy. Synovial fluid (SF) in seven patients with amyloid arthropathy associated with chronic renal failure undergoing haemodialysis were studied. The SF and synovial samples of 10 consecutive patients with seronegative mono- or oligoarthritis served as controls. Six of the seven patients with amyloid positive synovial biopsy specimens showed amyloid in their SF. No amyloid was found in the synovial tissue or fluid of the 10 patients in the control group, the sensitivity being 87.7%. The finding of amyloid in SF was highly reproducible, showing its presence in the same joint on several occasions. The deposits were Congophilia resistant to potassium permanganate pretreatment, and the immunohistochemical analysis proved that they contained beta 2 microglobulin. The high sensitivity and good reproducibility of the method shows that the finding of amyloid in SF is sufficient for the diagnosis of synovial amyloidosis. It is possible to perform immunohis
Note: Reproducció digital del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 1987, vol. 46, núm. 4, p. 324-326
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Fonaments Clínics)

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