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Title: Loss of bone mineral density in premenopausal women with systemic lupus erythematosus
Author: Formiga Pérez, Francesc
Moga Sempere, Isabel
Nolla Solé, Joan Miquel
Pac Ferraz, Visitación
Mitjavila Villeró, Francesca
Roig Escofet, D. (Daniel)
Keywords: Densitometria òssia
Lupus eritematós
Bone densitometry
Lupus erythematosus
Issue Date: 1995
Publisher: BMJ Group
Abstract: OBJECTIVE--To evaluate bone mineral density (BMD) in premenopausal patients with systemic lupus erythematosus (SLE). METHODS--We measured BMD by dual energy x ray absorptiometry at lumbar vertebrae L2-4 and at the right femoral neck in 74 premenopausal white patients (mean age 30.8 years) with SLE who were receiving glucocorticoid therapy, and in a control group. RESULTS--The mean cumulative dose of prednisone was 32.5 (SD 28) g. The mean dose at the time of absorptiometry was 13.7 (6.9) mg. BMD was significantly reduced at the spine and at the femoral neck in SLE patients when compared with the control group: L2-4 = 0.943 (0.1) g/cm2 v 1.038 (0.1) g/cm2 (p < 0.001); femoral neck = 0.766 (0.09) g/cm2 v 0.864 (0.1) g/cm2 (p < 0.001). Nine patients (12.1%), but none of the control group, had a BMD less than the reference range. CONCLUSION--BMD in premenopausal patients with SLE was less than that in a control group and less than the reference range of values defining the presence of osteoporosis in 12.1%. We did not find a relationship between BMD and either cumulative or baseline dose of corticosteroid therapy.
Note: Reproducció digital del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 1995, vol. 54, núm. 4, p. 274-276
Related resource:
ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Medicina)

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