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Title: HLA class II antigens (DR, DQ LOCI) and peripheral arthritis in ankylosing spondylitis.
Author: Sanmartí Sala, Raimon
Ercilla González, M. Guadalupe
Brancós Cunill, Ma. Antonia
Cid Xutglà, M. Cinta
Collado Cruz, Antonio
Rotés Querol, J. (Jaume), 1921-2008
Keywords: Espondiloartritis anquilosant
Estudi de casos
Antígens HLA
HLA histocompatibility antigens
Case studies
Ankylosing spondylitis
Issue Date: 1987
Publisher: BMJ Group
Abstract: Fifty one patients with ankylosing spondylitis (AS) were typed for HLA-A, B, C, DR, and DQ antigens. The antigen frequencies were compared with those of a normal population and with a B27 positive control group. All but one of the patients with AS were HLA-B27 positive. A positive linkage disequilibrium between Cw1, Cw2, DR1, and the B27 antigen was observed. Patients with AS showed a significant increase in DQw2 antigen compared with the B27 positive control group. No differences in antigenic frequencies were observed in patients having peripheral arthritis and patients with only axial involvement. Seven out of nine patients (78%) with an erosive peripheral arthritis were DR7 positive, suggesting that DR7 or genes closely linked could be related with a more aggressive peripheral joint involvement in patients with AS.
Note: Reproducció digital del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 1987, vol. 46, núm. 7, p. 497-500
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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