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Title: Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity
Author: Cervera i Segura, Ricard, 1960-
Navarro López, Margarita
López-Soto, Alfonso
Cid Xutglà, M. Cinta
Font Franco, Josep, 1953-2006
Esparza Sánchez, Jordi
Reverter Calatayud, Juan Carlos
Monteagudo Terres, Juan
Ingelmo Morín, Miguel
Urbano Márquez, A. (Álvaro)
Keywords: Malaltia de Behçet
Behçet's disease
Issue Date: 1994
Publisher: BMJ Group
Abstract: OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.
Note: Reproducció digital del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 1994, vol. 53, núm. 4, p. 265-267
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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