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Title: Nogo, myelin and axonal regeneration
Author: Mingorance Jiménez, Alfredo
Soriano García, Eduardo
Río Fernández, José Antonio del
Keywords: Neurobiologia
Regeneració del sistema nerviós
Nervous system regeneration
Issue Date: 2004
Publisher: Institut d'Estudis Catalans
Abstract: Adult mammalian central nervous system (CNS) axons have very limited capacity of regrowth after injury. In recent years, advances in the field of axonal regeneration have proved that neurons do not regenerate, mainly because of the presence of inhibitory molecules. Myelin-associated proteins limit axonal outgrowth and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo, MAG and OMgp, share a common neuronal receptor (NgR), and together represent one of the main hindrances to neuronal regeneration. The recent molecular cloning of Nogo and its receptors opened a new door to the study of axon regeneration. However, many of the elements involved in the myelin inhibitory pathway are still unknown, and the preliminary experiments with knockout mice are rather contradictory. Because of this complexity, Nogo and NgR need to be characterized before precise strategies to promote axon regeneration in the CNS can be designed.
Note: Reproducció digital del document publicat a:
It is part of: Contributions to Science, 2004, vol. 2, num. 4, p. 499-512
ISSN: 1575-6343
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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