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Title: Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC
Author: Junza Martínez, Alexandra
Amatya, Rameshwari
Barrón Bueno, Dolores
Barbosa Torralbo, José
Keywords: Llet
Química analítica
Quinolone antibacterial agents
Analytical chemistry
Issue Date: 2011
Publisher: Elsevier
Abstract: The aim of this study was to develop and validate an analytical method to simultaneously determine European Union-regulated beta-lactams (penicillins and cephalosporins) and quinolones in cow milk. The procedure involves a new solid phase extraction (SPE) to clean-up and pre-concentrate the three series of antibiotics before analysis by liquid chromatography¿tandem mass spectrometry (LC-MS/MS) and ultra-high-performance liquid chromatography¿tandem mass spectrometry (UPLC-MS/MS). LC-MS/MS and UPLC-MS/MS techniques were also compared. The method was validated according to the Directive 2002/657/EC and subsequently applied to 56 samples of raw cow milk supplied by the Laboratori Interprofessional Lleter de Catalunya (ALLIC) (Laboratori Interprofessional Lleter de Catalunya, Control Laboratory Interprofessional of Milk of Catalunya).
Note: Versió preprint del document publicat a:
Journal of Chromatography B, 2011, vol. 879, núm. 25, p. 2601¿2610
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ISSN: 1570-0232
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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