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Title: Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT
Author: Bullich Roig, Santiago
Ros Puig, Domènec
Cot Sanz, Albert
Falcón, C.
Muxí Pradas, África
Pavía Segura, Javier
Keywords: Tomografia
Mètode de Montecarlo
Medicina nuclear
Monte Carlo method
Nuclear medicine
Issue Date: 2003
Publisher: The American Association of Physicists in Medicine
Abstract: Simulation is a useful tool in cardiac SPECT to assess quantification algorithms. However, simple equation-based models are limited in their ability to simulate realistic heart motion and perfusion. We present a numerical dynamic model of the left ventricle, which allows us to simulate normal and anomalous cardiac cycles, as well as perfusion defects. Bicubic splines were fitted to a number of control points to represent endocardial and epicardial surfaces of the left ventricle. A transformation from each point on the surface to a template of activity was made to represent the myocardial perfusion. Geometry-based and patient-based simulations were performed to illustrate this model. Geometry-based simulations modeled ~1! a normal patient, ~2! a well-perfused patient with abnormal regional function, ~3! an ischaemic patient with abnormal regional function, and ~4! a patient study including tracer kinetics. Patient-based simulation consisted of a left ventricle including a realistic shape and motion obtained from a magnetic resonance study. We conclude that this model has the potential to study the influence of several physical parameters and the left ventricle contraction in myocardial perfusion SPECT and gated-SPECT studies.
Note: Reproducció del document publicat a
It is part of: Medical Physics, 2003, vol. 30, num. 8, p. 1968-1975
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ISSN: 0094-2405
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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