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Title: | Activation of Srk1 by the Mitogen-activated Protein Kinase Sty1/Spc1 Precedes Its Dissociation from the Kinase and Signals Its Degradation |
Author: | López Avilés, Sandra Lambea Martínez, Eva Moldón Vara, Alberto Grande Robles, Maribel Fajardo, Alba Rodríguez-Gabriel, Miguel A. Hidalgo Hernando, Elena Aligué i Alemany, Rosa Maria |
Keywords: | Proteïnes quinases Llevats Cicle cel·lular Protein kinases Yeast Cell cycle |
Issue Date: | 1-Feb-2008 |
Publisher: | American Society for Cell Biology |
Abstract: | Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress. Here we show that Sty1/Spc1 is bound to its target, the Srk1 kinase, when the signaling pathway is inactive. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both activation of Srk1 kinase, which negatively regulates cell cycle progression by inhibiting Cdc25, and dissociation of Srk1 from the SAPK, which leads to Srk1 degradation by the proteasome. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1091/mbc.E07-07-0639 |
It is part of: | Molecular Biology of the Cell, 2008, vol. 19, núm. 4, p. 1670-1679 |
URI: | http://hdl.handle.net/2445/25183 |
Related resource: | http://dx.doi.org/10.1091/mbc.E07-07-0639 |
ISSN: | 1059-1524 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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