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Title: Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
Author: Ferrer, Isidro (Ferrer Abizanda)
Tuñón, Teresa
Serrano Piñol, M. Teresa
Casas, Rosaura
Alcántara Horrillo, Soledad
Zújar, M. J.
Rivera, R. M.
Keywords: Esclerosi lateral amiotròfica
Lòbul frontal
Amyotrophic lateral sclerosis
Frontal lobe
Issue Date: 1993
Publisher: BMJ Publishing Group
Abstract: The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.
Note: Reproducció del document publicat a:
It is part of: Journal of Neurology Neurosurgery and Psychiatry, 1993, num. 56, p. 257-261
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ISSN: 0022-3050
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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