Please use this identifier to cite or link to this item:
Title: Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
Author: González, Sergio
Moreno-Delgado, David
Moreno Guillén, Estefanía
Pérez Capote, Kamil
Franco Fernández, Rafael
Mallol Montero, Josefa
Cortés Tejedor, Antonio
Casadó, Vicent
Lluís i Biset, Carme
Ortiz, Jordi
Ferré, Sergi
Canela Campos, Enric I.
McCormick, Peter J.
Keywords: Glàndula pineal
Receptors adrenèrgics
Pineal gland
Adrenaline receptors
Issue Date: 19-Jun-2012
Publisher: Public Library of Science (PLoS)
Abstract: The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors. Through alpha18-D4 and ß1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D4 was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs.
Note: Reproducció del document publicat a:
It is part of: PLoS Biology, 2012, vol. 10, num. 6
Related resource:
ISSN: 1544-9173
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
614308.pdf1.12 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons