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Title: Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminary prospective observational study
Author: Sardà Sánchez, Marta
Calzada Hernández, Joan
Hernández Bou, Susanna
Claret Teruel, Gemma
Velasco Rodríguez, Jesús
Luaces Cubells, Carles
Keywords: Infants malalts
Pneumònia adquirida a la comunitat
Marcadors bioquímics
Sick children
Community-acquired pneumonia
Biochemical markers
Issue Date: 20-Jun-2012
Publisher: BioMed Central
Abstract: BackgroundIn adult population with community acquired pneumonia high levels of pro-adrenomedullin (pro-ADM) have been shown to be predictors of worse prognosis. The role of this biomarker in pediatric patients had not been analyzed to date. The objective of this study is to know the levels of pro-ADM in children with community acquired pneumonia (CAP) and analyze the relation between these levels and the patients¿ prognosis.FindingsProspective observational study including patients attended in the emergency service (January to October 2009) admitted to hospital with CAP and no complications at admission. The values for pro-ADM were analyzed in relation to: need for oxygen therapy, duration of oxygen therapy, fever and antibiotic therapy, complications, admission to the intensive care unit, and length of hospital stay. Fifty patients were included. Ten presented complications (7 pleural effusion). The median level of pro-ADM was 1.0065¿nmol/L (range 0.3715 to 7.2840¿nmol/L). The patients presenting complications had higher levels of pro-ADM (2.3190 vs. 1.1758¿nmol/L, p¿=¿0.013). Specifically, the presence of pleural effusion was associated with higher levels of pro-ADM (2.9440 vs. 1.1373¿nmol/L, p¿<¿0.001).ConclusionsIn our sample of patients admitted to hospital with CAP, pro-ADM levels are related to the development of complications during hospitalization.
Note: Reproducció del document publicat a:
It is part of: BMC Research Notes 2012, 5:363
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ISSN: 1756-0500
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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