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Title: Clinical pharmacokinetics of mycophenolic acid and its metabolites in solid organ transplant recipient
Author: Colom Codina, Helena
Lloberas Blanch, Núria
Caldés, Ana
Andreu, Franc
Torras Ambròs, Joan
Oppenheimer Salinas, Federico
Sánchez-Plumed, Jaime
Gentil, Miguel A.
Kuypers, Dirk R.
Brunet i Serra, Mercè
Ekberg, Henrik
Grinyó Boira, Josep M.
Keywords: Farmacologia
Metabolisme dels medicaments
Drugs metabolism
Issue Date: 2012
Publisher: Transworld Research Network
Abstract: Mycophenolate mofetil (MMF), an ester prodrug of the immunosuppressant mycophenolic acid (MPA), is widely used for maintenance immunosuppressive therapy and prevention of renal allograft rejection in renal transplant recipients. MPA inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the “de novo” synthesis of purine nucleotides, thus suppressing both T-cell and B-cell proliferation. MPA shows a complex pharmacokinetics with considerable interand intra- patient by between- and within patient variabilities associated to MPA exposure. Several factors may contribute to it. The pharmacokinetic modeling according to the population pharmacokinetic approach with the non-linear mixed effects models has shown to be a powerful tool to describe the relationships between MMF doses and the MPA exposures and also to identify potential predictive patients’ demographic and clinical characteristics for dose tailoring during the post-transplant immunosuppresive treatment.
Note: Podeu consultar el llibre complet a:
Note: Reproducció del capítol 11 del llibre publicat a:
It is part of: Recent Advances in Pharmaceutical Sciences II, 2012, Editor: Diego Muñoz-Torrero, Diego Haro and Joan Vallès, Chapter 11, p. 183-201.
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Appears in Collections:Llibres / Capítols de llibre (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Llibres / Capítols de llibre (Medicina)
Llibres / Capítols de llibre (Ciències Clíniques)

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