Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/34586
Title: | An enantioselective entry to cis-perhydroisoquinolines |
Author: | Amat Tusón, Mercedes Pérez Bosch, Maria Minaglia, Annamaria Tania Casamitjana i Badia, Núria Bosch Cartes, Joan |
Keywords: | Isoquinolina Isoquinoline |
Issue Date: | 25-Jul-2005 |
Publisher: | American Chemical Society |
Abstract: | An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/ol051242c |
It is part of: | Organic Letters, 2005, vol. 7, num. 17, p. 3653-3656 |
URI: | http://hdl.handle.net/2445/34586 |
Related resource: | http://dx.doi.org/10.1021/ol051242c |
ISSN: | 1523-7060 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
568510.pdf | 139.11 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.