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http://hdl.handle.net/2445/34586| Title: | An enantioselective entry to cis-perhydroisoquinolines |
| Author: | Amat Tusón, Mercedes Pérez Bosch, Maria Minaglia, Annamaria Tania Casamitjana i Badia, Núria Bosch Cartes, Joan |
| Keywords: | Isoquinolina Isoquinoline |
| Issue Date: | 25-Jul-2005 |
| Publisher: | American Chemical Society |
| Abstract: | An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/ol051242c |
| It is part of: | Organic Letters, 2005, vol. 7, num. 17, p. 3653-3656 |
| URI: | http://hdl.handle.net/2445/34586 |
| Related resource: | http://dx.doi.org/10.1021/ol051242c |
| ISSN: | 1523-7060 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 568510.pdf | 139.11 kB | Adobe PDF | View/Open |
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