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http://hdl.handle.net/2445/42863| Title: | Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression. |
| Author: | Rodríguez García, Marta Climent, Núria Oliva, Harold Casanova Güell, Víctor Franco Fernández, Rafael León García, Agathe Gatell, José M. García, Felipe Gallart, Teresa |
| Keywords: | VIH (Virus) Immunologia HIV (Viruses) Immunology |
| Issue Date: | 2010 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0009436 |
| It is part of: | PLoS One, 2010, vol. 5, num. 2, p. e9436-e9436 |
| URI: | http://hdl.handle.net/2445/42863 |
| Related resource: | http://dx.doi.org/10.1371/journal.pone.0009436 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Medicina) |
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