Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/43193
Title: | Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation |
Author: | Vitureira, Natalia Andrés, Rosa María Pérez Martínez, Mª Esther Martínez García, Albert Bribián Arruego, Ana Blasi Cabús, Joan Chelliah, Shierley López Doménech, Guillermo Castro, Fernando de Burgaya i Márquez, Ferran McNagny, Kelly Soriano García, Eduardo |
Keywords: | Neurobiologia del desenvolupament Developmental neurobiology |
Issue Date: | 2010 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-of-function reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0012003 |
It is part of: | PLoS One, 2010, vol. 5, num. 8, p. e12003 |
URI: | http://hdl.handle.net/2445/43193 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0012003 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
584593.pdf | 7.73 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License