Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/43201
Title: | Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta |
Author: | Liesa Torre-Marín, Montserrat Borda d'Agua, Bárbara Medina Gómez, Gema Lelliott, Christopher J. Paz, José Carlos Rojo, Manuel Palacín Prieto, Manuel Vidal-Puig, Antonio Zorzano Olarte, Antonio |
Keywords: | Mitocondris Regulació genètica Mitochondria Genetic regulation |
Issue Date: | Oct-2008 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. Methodology/Principal Findings Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1β is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1β increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1β-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1β increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor α (ERRα). Conclusions/Significance Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1β in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0003613 |
It is part of: | PLoS One, 2008, vol. 3, num. 10, p. e3613 |
URI: | http://hdl.handle.net/2445/43201 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0003613 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
567847.pdf | 473.88 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License