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http://hdl.handle.net/2445/43315
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DC Field | Value | Language |
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dc.contributor.author | Llagostera Martín, Esther | - |
dc.contributor.author | Catalucci, Daniele | - |
dc.contributor.author | Martí, Luc | - |
dc.contributor.author | Liesa Torre-Marín, Montserrat | - |
dc.contributor.author | Camps Camprubí, Marta | - |
dc.contributor.author | Ciaraldi, Theodore P. | - |
dc.contributor.author | Kondo, Richard | - |
dc.contributor.author | Reddy, Sita | - |
dc.contributor.author | Dillmann, Wolfgang H. | - |
dc.contributor.author | Palacín Prieto, Manuel | - |
dc.contributor.author | Zorzano Olarte, Antonio | - |
dc.contributor.author | Ruiz-Lozano, Pilar | - |
dc.contributor.author | Gomis, Ramon, 1946- | - |
dc.contributor.author | Kaliman, Perla | - |
dc.date.accessioned | 2013-05-10T12:21:03Z | - |
dc.date.available | 2013-05-10T12:21:03Z | - |
dc.date.issued | 2007-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43315 | - |
dc.description.abstract | Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated with a pathogenic effect of the repeat expansions. Here we show that DMPK itself is a positive modulator of insulin action. DMPK-deficient (dmpk−/−) mice exhibit impaired insulin signaling in muscle tissues but not in adipocytes and liver, tissues in which DMPK is not expressed. Dmpk−/− mice display metabolic derangements such as abnormal glucose tolerance, reduced glucose uptake and impaired insulin-dependent GLUT4 trafficking in muscle. Using DMPK mutants, we show that DMPK is required for a correct intracellular trafficking of insulin and IGF-1 receptors, providing a mechanism to explain the molecular and metabolic phenotype of dmpk−/− mice. Taken together, these findings indicate that reduced DMPK expression may directly influence the onset of insulin-resistance in DM1 patients and point to dmpk as a new candidate gene for susceptibility to type 2-diabetes. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0001134 | - |
dc.relation.ispartof | PLoS One, 2007, num. 11, p. e1134 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0001134 | - |
dc.rights | cc-by (c) Llagostera Martín, Esther et al., 2007 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Fisiologia patològica | - |
dc.subject.classification | Proteïnes quinases | - |
dc.subject.classification | Malalties de l'aparell locomotor | - |
dc.subject.classification | Insulina | - |
dc.subject.other | Pathological physiology | - |
dc.subject.other | Protein kinases | - |
dc.subject.other | Enfermedades del aparato locomotor | - |
dc.subject.other | Insulin | - |
dc.title | Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 567842 | - |
dc.date.updated | 2013-05-10T12:21:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 17987120 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Medicina) |
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567842.pdf | 620.02 kB | Adobe PDF | View/Open |
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