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Title: | Factors Associated to Duration of Hepatitis A Outbreaks: Implications for Control |
Author: | Torner Gràcia, Núria Broner, Sonia Judith Martínez, Ana Tortajada, Cecilia García de Olalla, Patricia Barrabeig i Fabregat, Irene Sala Farré, Maria Rosa Camps, Neus Minguell, Sofia Alvarez, Josep Ferrús, Gloria Torra, Roser Godoy i García, Pere Domínguez García, Àngela Hepatitis A Surveillance Group of Catalonia |
Keywords: | Virus de l'hepatitis A Epidemiologia Hepatitis A virus Epidemiology |
Issue Date: | 15-Feb-2012 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 105 persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0031339 |
It is part of: | PLoS One, 2012, vol. 7, num. 2, p. e31339 |
URI: | http://hdl.handle.net/2445/43602 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0031339 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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