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DC Field | Value | Language |
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dc.contributor.author | Guasch-Ferré, Marta | - |
dc.contributor.author | Bulló, Mònica | - |
dc.contributor.author | Costa, Bernardo | - |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- | - |
dc.contributor.author | Ibarrola Jurado, Núria | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Barrio, Francisco | - |
dc.contributor.author | Salas Salvadó, Jordi | - |
dc.date.accessioned | 2013-06-11T08:15:44Z | - |
dc.date.available | 2013-06-11T08:15:44Z | - |
dc.date.issued | 2012-03-19 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/44161 | - |
dc.description.abstract | Introduction: To develop and test a diabetes risk score to predict incident diabetes in an elderly Spanish Mediterranean population at high cardiovascular risk. Materials and Methods: A diabetes risk score was derived from a subset of 1381 nondiabetic individuals from three centres of the PREDIMED study (derivation sample). Multivariate Cox regression model ß-coefficients were used to weigh each risk factor. PREDIMED-personal Score included body-mass-index, smoking status, family history of type 2 diabetes, alcohol consumption and hypertension as categorical variables; PREDIMED-clinical Score included also high blood glucose. We tested the predictive capability of these scores in the DE-PLAN-CAT cohort (validation sample). The discrimination of Finnish Diabetes Risk Score (FINDRISC), German Diabetes Risk Score (GDRS) and our scores was assessed with the area under curve (AUC). Results: The PREDIMED-clinical Score varied from 0 to 14 points. In the subset of the PREDIMED study, 155 individuals developed diabetes during the 4.75-years follow-up. The PREDIMED-clinical score at a cutoff of $6 had sensitivity of 72.2%, and specificity of 72.5%, whereas AUC was 0.78. The AUC of the PREDIMED-clinical Score was 0.66 in the validation sample (sensitivity = 85.4%; specificity = 26.6%), and was significantly higher than the FINDRISC and the GDRS in both the derivation and validation samples. Discussion: We identified classical risk factors for diabetes and developed the PREDIMED-clinical Score to determine those individuals at high risk of developing diabetes in elderly individuals at high cardiovascular risk. The predictive capability of the PREDIMED-clinical Score was significantly higher than the FINDRISC and GDRS, and also used fewer items in the questionnaire. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0033437 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 3, p. e33437 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0033437 | - |
dc.rights | cc-by (c) Guasch Ferré, M. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Espanya | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Spain | - |
dc.title | A risk score to predict type 2 diabetes mellitus in an elderly spanish mediterranean population at high cardiovascular risk. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 612505 | - |
dc.date.updated | 2013-06-11T08:15:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22442692 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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