Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/44445
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCampayo Guillaumes, Marc-
dc.contributor.authorNavarro Ponz, Alfons-
dc.contributor.authorViñolas Segarra, Núria-
dc.contributor.authorTejero Villalba, Rut-
dc.contributor.authorMuñoz García, Carmen-
dc.contributor.authorDíaz Sánchez, Tania-
dc.contributor.authorMarrades Sicart, Ramon Ma.-
dc.contributor.authorCabanas, Maria L.-
dc.contributor.authorGimferrer Garolera, José Ma.-
dc.contributor.authorGascón, Pere-
dc.contributor.authorRamírez Ruz, J. (José)-
dc.contributor.authorMonzó Planella, Mariano-
dc.date.accessioned2013-06-26T18:25:35Z-
dc.date.available2013-06-26T18:25:35Z-
dc.date.issued2011-07-25-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2445/44445-
dc.description.abstractMicroRNAs (miRNAs) play an important role in carcinogenesis through the regulation of their target genes. miRNA-related single nucleotide polymorphisms (miR-SNPs) can affect miRNA biogenesis and target sites and can alter microRNA expression and functions. We examined 11 miR-SNPs, including 5 in microRNA genes, 3 in microRNA binding sites and 3 in microRNA-processing machinery components, and evaluated time to recurrence (TTR) according to miR-SNP genotypes in 175 surgically resected non-small-cell lung cancer (NSCLC) patients. Significant differences in TTR were found according to KRT81 rs3660 (median TTR: 20.3 months for the CC genotype versus 86.8 months for the CG or GG genotype; P = 0.003) and XPO5 rs11077 (median TTR: 24.7 months for the AA genotype versus 73.1 months for the AC or CC genotypes; P = 0.029). Moreover, when patients were divided according to stage, these differences were maintained for stage I patients (P = 0.002 for KRT81 rs3660; P<0.001 for XPO5 rs11077). When patients were divided into sub-groups according to histology, the effect of the KRT81 rs3660 genotype on TTR was significant in patients with squamous cell carcinoma (P = 0.004) but not in those with adenocarcinoma. In the multivariate analyses, the KRT81 rs3660 CC genotype (OR = 1.8; P = 0.023) and the XPO5 rs11077 AA genotype (OR = 1.77; P = 0.026) emerged as independent variables influencing TTR. Immunohistochemical analyses in 80 lung specimens showed that 95% of squamous cell carcinomas were positive for KRT81, compared to only 19% of adenocarcinomas (P<0.0001). In conclusion, miR-SNPs are a novel class of SNPs that can add useful prognostic information on the clinical outcome of resected NSCLC patients and may be a potential key tool for selecting high-risk stage I patients. Moreover, KRT81 has emerged as a promising immunohistochemical marker for the identification of squamous cell lung carcinoma.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: 10.1371/journal.pone.0022509-
dc.relation.ispartofPLoS One, 2011, vol. 6, num. 7, p. e0022509-
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0022509-
dc.rightscc-by (c) Campayo Guillaumes, Marc et al., 2011-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Fonaments Clínics)-
dc.subject.classificationMicro RNAs-
dc.subject.classificationCarcinogènesi-
dc.subject.otherMicroRNAs-
dc.subject.otherCarcinogenesis-
dc.titleA dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec597285-
dc.date.updated2013-06-26T18:25:36Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid21799879-
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

Files in This Item:
File Description SizeFormat 
597285.pdf2.87 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons