Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/50283
Title: | Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening |
Author: | Pérez Torras, Sandra Vidal Pla, Anna Miquel Morera, Rosa Almendro Navarro, Vanessa Fernández-Cruz, Laureano Navarro Colás, Salvador Maurel Santasusana, Joan Carbó Carbó, Neus Gascón, Pere Mazo Sánchez, Adela |
Keywords: | Càncer Pàncrees Genètica molecular Teràpia genètica Cancer Pancreas Molecular genetics Gene therapy |
Issue Date: | 1-Nov-2011 |
Publisher: | IOS Press |
Abstract: | Background Efforts to identify novel therapeutic options for human pancreatic ductal adenocarcinoma (PDAC) have failed to result in a clear improvement in patient survival to date. Pancreatic cancer requires efficient therapies that must be designed and assayed in preclinical models with improved predictor ability. Among the available preclinical models, the orthotopic approach fits with this expectation, but its use is still occasional. Methods An in vivo platform of 11 orthotopic tumor xenografts has been generated by direct implantation of fresh surgical material. In addition, a frozen tumorgraft bank has been created, ensuring future model recovery and tumor tissue availability. Results Tissue microarray studies allow showing a high degree of original histology preservation and maintenance of protein expression patterns through passages. The models display stable growth kinetics and characteristic metastatic behavior. Moreover, the molecular diversity may facilitate the identification of tumor subtypes and comparison of drug responses that complement or confirm information obtained with other preclinical models. Conclusions This panel represents a useful preclinical tool for testing new agents and treatment protocols and for further exploration of the biological basis of drug responses. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1007/s13402-011-0049-1 |
It is part of: | Analytical Cellular Pathology / Cellular Oncology, 2011, vol. 34, num. 6, p. 511-521 |
URI: | http://hdl.handle.net/2445/50283 |
Related resource: | http://dx.doi.org/10.1007/s13402-011-0049-1 |
ISSN: | 1570-5870 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
625113.pdf | 907.53 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.