Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/51445
Title: | Changes in lipoprotein lipase modulate tissular energy supply during stress |
Author: | Ricart i Jané, David Cejudo Martín, María del Pilar Peinado Onsurbe, Julia López Tejero, M. Dolores Llobera i Sande, Miquel |
Keywords: | Lipoproteïnes Lipases Teixit adipós Rates (Animals de laboratori) Efecte de l'estrès sobre els animals Lipoproteins Lipase Adipose tissues Rats as laboratory animals Effect of stress on animals |
Issue Date: | Oct-2005 |
Publisher: | American Physiological Society |
Abstract: | We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat. Stress was produced by body immobilization (Immo): the rat's limbs were taped to metal mounts, and its head was placed in a plastic tube. Chronic stress (2 h daily of Immo) decreased total LPL activity in mesenteric and epididymal white adipose tissue (WAT) and was accompanied by a weight reduction of these tissues. In limb muscle, heart, and adrenals, total LPL activity and mRNA levels increased, and, in plasma, LPL activity and mass also increased. Acute stress (30-min Immo) caused a decrease in total LPL activity only in retroperitoneal WAT and an increase in preheparin plasma active LPL, but the overall weight of this tissue did not vary significantly. We propose an early release of the enzyme from this tissue into the bloodstream by some unknown extracellular pathways or other local mechanisms. These changes in this key energy-regulating enzyme are probably induced by catecholamines. They modify the flow of energy substrates between tissues, switching the WAT from importer to exporter of free fatty acids and favoring the uptake by muscle of circulating triacylglycerides for energy supply. Moreover, we found that acute stress almost doubled blood flow in all WAT studied, favoring the export of free fatty acids. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1152/japplphysiol.00971.2004 |
It is part of: | Journal of Applied Physiology, 2005, num. |
URI: | http://hdl.handle.net/2445/51445 |
Related resource: | http://dx.doi.org/10.1152/japplphysiol.00971.2004 |
ISSN: | 8750-7587 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
574408.pdf | 495.31 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.