Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/53332
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dc.contributor.authorSaurí Duran, Jaume-
dc.contributor.authorMillán, D.-
dc.contributor.authorSuñé i Negre, Josep M. (Josep Maria)-
dc.contributor.authorPérez Lozano, Pilar-
dc.contributor.authorSarrate Arjona, Rocio-
dc.contributor.authorFábregas, A. (Anna)-
dc.contributor.authorCarrillo Sánchez, Carolina-
dc.contributor.authorMiñarro Carmona, Montserrat-
dc.contributor.authorTicó Grau, Josep R.-
dc.contributor.authorGarcía Montoya, Encarna-
dc.date.accessioned2014-04-08T09:05:35Z-
dc.date.available2014-04-08T09:05:35Z-
dc.date.issued2014-01-30-
dc.identifier.issn0378-5173-
dc.identifier.urihttp://hdl.handle.net/2445/53332-
dc.description.abstractThe SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.-
dc.format.extent8 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029-
dc.relation.ispartofInternational Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45-
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2013.11.029-
dc.rights(c) Elsevier B.V., 2014-
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)-
dc.subject.classificationComprimits (Medicina)-
dc.subject.classificationMedicació oral-
dc.subject.classificationExcipients-
dc.subject.classificationControl de qualitat-
dc.subject.classificationMedicaments d'alliberament retardat-
dc.subject.classificationTecnologia farmacèutica-
dc.subject.classificationPólvores (Farmàcia)-
dc.subject.otherTablets (Medicine)-
dc.subject.otherOral medication-
dc.subject.otherExcipients-
dc.subject.otherQuality control-
dc.subject.otherDelayed-action drugs-
dc.subject.otherPharmaceutical technology-
dc.subject.otherPowders (Pharmacy)-
dc.titleThe use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec630651-
dc.date.updated2014-04-08T09:05:36Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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